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制备了壳聚糖-甘油磷酸钠温敏凝胶,讨论了壳聚糖的脱乙酰度,浓度和β-GP的浓度等工艺参数对温敏凝胶理化性能的影响,通过X射线,红外光谱和扫描电镜等测试手段表征了温敏凝胶材料的成分组成和微观结构,讨论了该体系的自凝化机理.

参考文献

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[2] Ruel Gariepy-E;Chenite A;Chaput C;Guirguis S;Leroux J .Characterization of thermosensitive chitosan gels for the sustained delivery of drugs.[J].International Journal of Pharmaceutics,2000(1/2):89-98.
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[5] Berger J;Reist M;Chenite A;Felt Baeyens O;Mayer JM;Gurny R .Pseudo-thermosetting chitosan hydrogels for biomedical application.[J].International Journal of Pharmaceutics,2005(1):17-25.
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[7] Ruel-Gariepy E.;Leclair G.;Hildgen P.;Gupta A.;Leroux JC. .Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2002(2/3):373-383.
[8] Jaepyoung Cho;Marie-Claude Heuzey;Andre Begin;Pierre J.Carreau .Physical Gelation of Chitosan in the Presence of beta-Glycerophosphate:The Effect of Temperature[J].Biomacromolecules,2005(6):3267-3275.
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