制备了烟碱/磷酸化壳聚糖纳米粒子水分散液.扫描电镜和激光散射结果表明,在pH值4.0～4.8之间,形成了稳定的烟碱/磷酸化壳聚糖纳米粒子.纳米粒子分散液的pH值从4.0上升到4.8,纳米粒子分散液的Zeta-电位下降.磷酸化壳聚糖和烟碱的体积比从2升至6,烟碱/磷酸化壳聚糖纳米粒子的粒径减小;纳米粒子的粒径随磷酸化壳聚糖溶液浓度的升高而显著增大.烟碱/磷酸化壳聚糖纳米粒子的平均粒径在300nm～800nm.随磷酸化壳聚糖和烟碱的质量比增大,烟碱/磷酸化壳聚糖纳米粒子的负载率增大,纳米粒子对烟碱的包封效率可以达到88.8％.
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