聚酰胺-胺型(PAMAM)树状聚合物是一种新兴的非病毒类纳米材料载体,在药物运载、基因治疗、重大疾病早期诊断等方面具有广阔的研究前景.但载体材料与其相关的免疫反应、细胞毒性以及安全性等方面的报道比较零散,没有进行过系统地归纳.对PAMAM树状聚合物的体外和体内毒性问题进行了归纳和总结,对通过表面修饰降低其毒性方面也进行了论述.
Polyamidoamine(PAMAM) dendrimers have to be one of the important candidates of non-virus carriers which have potential foreground in the fields of drug delivery,gene therapy and the early diagnosis of major diseases.However,immune response,cell toxicity,as well as security associated with drug delivery are reported scatteredly.The toxicity of in vitro and in vivo testing,as well as improvement of biocompatibility of PAMAM by surface engineering are reviewed.
参考文献
| [1] | Rosenfeld M A;Siegfried W et al.Adenovirus-mediated transfer of a recombinant alpha l-antitrypsin gene to the lung epithelium in vivo[J].Science,1991,252(5004):431. |
| [2] | Temin H M .Safety considerations in somatic gene therapy of human disease with retrovirus vectors[J].Human Gene Therapy,1990,1(02):111. |
| [3] | Sadler K J;Tam P .Peptide dendrimer:Applications and synthesis[J].Journal of Biotechnology,2002,90(3-4):195. |
| [4] | Roberts J C;Bhalgat M K;Zera R T.Preliminary biological evaluation of polyamidoamine (PAMAM) Starburstk dendrimers[J].Journal of Biomedical Materials Research,1996(30):53. |
| [5] | Malik N.;Klopsch R.;Lorenz K.;Frey H.;Weener JW. Meijer EW.;Paulus W.;Duncan R.;Wiwattanapatapee R. .Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled polyamidoamine dendrimers in vivo[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2000(1/2):133-148. |
| [6] | 赵光,叶玲,张瑾,王喆.生物材料聚酰胺-胺树状大分子合成及其体外细胞相容性评价[J].中国生物医学工程学报,2005(06):750-754. |
| [7] | Kitchens KM;Kolhatkar RB;Swaan PW;Eddington ND;Ghandehari H .Transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: Influence of size, charge and fluorescent labeling.[J].Pharmaceutical research,2006(12):2818-2826. |
| [8] | Yang H;Kao W J .Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery[J].Int J Nanomed,2007,2:89. |
| [9] | Fuchs S.;Kapp T.;Otto H.;Schoneberg T.;Franke P.;Gust R.;Schluter AD. .A surface-modified dendrimer set for potential application as drug delivery vehicles: Synthesis, in vitro toxicity, and intracellular localization [Review][J].Chemistry: A European journal,2004(5):1167-1192. |
| [10] | Fischer D.;Li YX.;Ahlemeyer B.;Krieglstein J.;Kissel T. .In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.[J].Biomaterials,2003(7):1121-1131. |
| [11] | Xyloyiannis M et al.PEG-dendron architecture influences endocytic capture and intracellular trafficking[J].Proceedings of the International Symposium on Controlled Release of Bioactive Materials,2003,30:149. |
| [12] | Duncan R;Izzo L .Dendrimer biocompatibility and toxicity.[J].Advanced drug delivery reviews,2005(15):2215-2237. |
| [13] | Kannan S et al.Dynamics of cellular entry and drug delivery by dendritic polymers into human lung epithelial carcinoma cells[J].Journal of Biomaterials Science:Polymer Edition,2004,15:311. |
| [14] | Kolhe P;Misra E;Kannan RM;Kannan S;Lieh Lai M .Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers.[J].International Journal of Pharmaceutics,2003(1/2):143-160. |
| [15] | Jevprasesphant R;Penny J;Attwood D;McKeown NB;D'Emanuele A .Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity.[J].Pharmaceutical research,2003(10):1543-1550. |
| [16] | El-Sayed M.;Ginski M.;Rhodes C.;Ghandehari H. .Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2002(3):355-365. |
| [17] | Roberts J C;Bhalgat M K et al.Preliminary biological evaluation of polyamidoamine (PAMAM) starburstTM dendri-mers[J].Journal of Biomedical Materials Research,1996,30(01):53. |
| [18] | Malik N;Evagorou EG;Duncan R .Dendrimer-platinate: a novel approach to cancer chemotherapy.[J].Anti-cancer drugs,1999(8):767-776. |
| [19] | Tomalia DA;Reyna LA;Svenson S .Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging.[J].Biochemical Society Transactions,2007(Pt.1):61-67. |
| [20] | Nigavekar SS;Sung LY;Llanes M;El Jawahri A;Lawrence TS;Becker CW;Balogh L;Khan MK .3H dendrimer nanoparticle organ/tumor distribution.[J].Pharmaceutical research,2004(3):476-483. |
| [21] | Heiden TC;Dengler E;Kao WJ;Heideman W;Peterson RE .Developmental toxicity of low generation PAMAM dendrimers in zebrafish.[J].Toxicology and Applied Pharmacology,2007(1):70-79. |
| [22] | Bhadra D;Bhadra S;Jain P;Jain NK .Pegnology: a review of PEG-ylated systems.[J].Die Pharmazie,2002(1):5-29. |
| [23] | Kojima C .Synthesis of polyamidoamine dendrimers having poly (ethylene glycol) crafts and their ability to encapsulate anticancer drugs[J].Bioconjugate Chemistry,2000,11(06):910. |
| [24] | Kenji K et al.Preparation and cytotoxic activity of poly (ethylene glycol)-modified poly (amidoamine) dendrimers bearing adriamycin[J].Biomaterials,2008,29:1664. |
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