Chitosan-hydroxyapatite (CS-HA) composite powders were synthesized via in situ co-precipitation method, through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid (SBF) containing appropriate amount of chitosan. The thermal evolution, microstructure and morphology were studied by TG-DTA (thermogravimetry-differential thermal analysis), XRD (X-ray diffraction), FTIR (Fourier transform infrared spectroscopy) and TEM (transmission electron microscopy). The in vitro bioactivity test showed that the obtained CS-HA composites had higher capability of inducing calcium ions deposition. Effects of CS-HA composites on the bioactivity and compressive strength of bioglass bone cement were investigated. The results indicated that the bioactivity of bioglass bone cement could be improved further when CS-HA composite powders were added into the cement, and appropriate amount of CS-HA additive was favorable for compressive strength improvement of bioglass bone cement.
参考文献
| [1] | X Shen;H Tong;T Jiang;Z Zhu P Wan J Hu .[J].Composites Science and Technology,2007,67(11-12):2238. |
| [2] | Wang H;Li Y;Zuo Y;Li J;Ma S;Cheng L .Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering.[J].Biomaterials,2007(22):3338-3348. |
| [3] | B Sreedhar;Y Aparna;M Sairam;N Hebalkar .[J].Journal of Applied Polymer Science,2007,105(02):928. |
| [4] | Q L Li;Z Q Chen;B W Darvell;Q Zeng G Li G M Ou M Y Wu .[J].Materials Letters,2006,60(29-30):3533. |
| [5] | M.Sivakumar;I.Manjubala .Preparation,characterization and in-vitro release of gentamicin from coralline hydroxyapatite-chitosan composite microspheres[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2002(3):281-288. |
| [6] | S L Chen;M Z Liu;S P Jin;B Wang .[J].International Journal of Pharmaceutics,2008,349(1-2):180. |
| [7] | S B Kim;Y J Kim;T L Yoon;S A Park I H Cho E J Kim I A Kim J W Shin .[J].BIOMATERIALS,2004,25:5715. |
| [8] | H Liu;H Li;W Cheng;Y Yang M Zhu C Zhou .[J].Acta Biomaterialia,2006,2(05):557. |
| [9] | Shi Z;Neoh KG;Kang ET;Wang W .Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles.[J].Biomaterials,2006(11):2440-2449. |
| [10] | E B Denkbas;E Kilicay;C Birlikseven;E Ozturk .[J].Reactive and Functional Polymers,2002,50:225. |
| [11] | Y Zhang;M Q Zhang .[J].Journal of Biomedical Materials Research,2002,62:378. |
| [12] | Z S Li;H R Ramay;K D Hauch;D M Xiao M Q Zhang .[J].Biomaterials,2005,26:3919. |
| [13] | I. Yamaguchi;K. Tokuchi;H. Fukuzaki .Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites[J].Journal of biomedical materials research, Part B. Applied biomaterials,2001(1):20-27. |
| [14] | I Yamaguchi;S Iizuka;A Osaka;H Monmad J Tanaka .[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2003,214:111. |
| [15] | F Chen;Z C Wang;C J Lin .[J].Materials Letters,2002,57:858. |
| [16] | A C Tas .[J].BIOMATERIALS,2000,21:1429. |
| [17] | S. Daglilar;M.E. Erkan .A study on bioceramic reinforced bone cements[J].Materials Letters,2007(7):1456-1459. |
| [18] | J V Rau;A Generosi;V V Smirnov;D Ferro V Rossi Albertini S M Barinov .[J].ACTA BIOMATERIALIA,2008,4(04):1089. |
| [19] | Fernandez E;Sarda S;Hamcerencu M;Vlad MD;Gel M;Valls S;Torres R;Lopez J .High-strength apatitic cement by modification with superplasticizers.[J].Biomaterials,2005(15):2289-2296. |
| [20] | LTNiu;JXLiu;LYu;YYJiang YZhao .[J].Chinese Materials Science Technology Equipment,2006,3(03):80. |
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