中枢神经系统损伤导致神经细胞死亡、组织破坏，造成神经功能永久性缺失，是长期困扰生物医学界的一大难题，目前尚无有效疗法。组织工程技术不仅能通过纳米生物材料为神经细胞和神经纤维生长提供结构支持，还能同时递送各种有利于神经再生修复的活性信号分子，有望在促进中枢神经损伤组织修复的同时，实现神经功能的重建，为中枢神经损伤再生修复带来希望。结合国内外有关中枢神经系统组织工程研究的最新进展，对中枢神经修复生物材料设计的主要策略、以及包括天然生物大分子和合成高分子在内的多种中枢神经修复生物材料的应用进行了详细综述。
Injuries to central nervous system （CNS） lead to severe and permanent neurological deficits. Tissue engi- neering is the most hopeful treatment by providing a regenerative environment in the CNS after injury as well as delivering ceils to the injured site. Artificial scaffolds not only provide a suitable support for axonal regeneration and cellular migra- tion, but delivery many bioactive molecules for neural repair. In this review we discuss the development of scaffolds and current strategies for designing scaffolds for CNS tissue engineering.
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