首先以辛酸亚锡为催化剂,消旋丙交酯(D,L-LA)与壳聚糖(CS)为原料,在超临界二氧化碳(scCO2)中合成了以PDLLA为基体、CS-g-PDLLA共聚物为填充相的共混体系,然后通过scCO2萃取/致孔技术原位构建了CS-g-PDLLA/PDLLA多孔支架材料.对共聚物的结构与性能、PDLLA的分子量进行了表征,对多孔支架的结构形态进行观察,并对支架材料的孔隙率进行测定.结果表明,以scCO2为反应介质,成功合成了PDLLA均聚物和CS-g-PDLLA共聚物,同时,通过改变原料比、反应温度和时间能在一定程度上调控共聚物的组成与PDLLA的分子量以及产率.CS-g-PDLLA/PDLLA多孔支架材料的孔洞分布均匀,孔洞连通性较好,孔内壁具有非常独特的长沟壑形微观结构,且CS-g-PDLLA填充相与PDLLA基体的相容性良好;减压速率和处理温度对多孔支架的结构形态有一定影响.
参考文献
| [1] | J.E.Bergsma,F.R.Rozema,R.R.M.Bos,G.Boering,W.C.de Bruijn,A.J.Pennings,In vivo degradation and biocompatibility study of in vitro pre-degraded as-polymerized polylactide particles,Biomaterials,16(4),267(1995) |
| [2] | V.Hasirci,K.Lewandrowski,J.D.Gresser,D.L.Wise,D.J.Trantolo.Versatility of biodegradable biopolymers:degradability and an in vivo application,Journal of Biotechnology,86(2),135(2001) |
| [3] | J.C.Middleton,A.J.Tipton,Synthetic biodegradable polymers as orthopedic devices,Biomateriais,21(23),2335(2000) |
| [4] | N.V.Majeti,R.Kumar,A review of chitin and chitosan applications Reactive and Functional Polymers,46(1),1(2000) |
| [5] | S.E.Kim,J.H.Park,Y.W.Cho,H.Chung,S.Y.Jeong,E.B.Jee,Porous chitosan scaffold containing microspheres loaded with transforming growth factor-β1:Implications for cartilage tissue engineering,Journal of Controlled Release,91(3),365(2003) |
| [6] | X.Qu,A.Wirsen,A.C.Albertsson,Synthesis and characterization of pH-sensitive hydrogels based on chitosan and D,L-Lactic acid,Journal of Applied Polymer Science,74(13),3193(1999) |
| [7] | Y.Liu,F.Tian,K.A.Hu,Synthesis and characterization of a brush-like copolymer of polylactide grafted onto chitosan,Carbohydrate Research,339(4),845(2004) |
| [8] | D.D.Hile,M.V.Pishko,Solvent-free protein encapsulation within biodegradable polymer foams,Drug Delivery,11(4),287(2004) |
| [9] | G.E.Luckachan,C.K.S.Pillai,Chitosan/oligo L-lactide graft copolymers:Effect of hydrophobic side chains on the physico-chemical properties and biodegradability,Carbohydrate Polymers,64(2),254(2006) |
| [10] | H.Feng,C.M.Dung,Synthesis and characterization of phthaloyl-chitosan-g-poly(L-lactide)using an organic catalyst,Carbohydrate Polymers,70(3),258(2007) |
| [11] | Y.Wu,Y.L.Zheng,W.L.Yang,C.C.Wang,J.H.Hu,S.K.Fu,Synthesis and characterization of a novel amphiphilic chitosan-pelylactide graft copolymer,Carbohydrate Polymers,59(2),165(2005) |
| [12] | A.Galia,R.D.Gregorio,G.Spadaro,O.Scialdone,G.Filardo,Grafting of maleic anhydride onto isotactic polypropylene in the presence of supercritical carbon dioxide as a solvent and swelling fluid,Macromolecules,37(12),4580(2004) |
| [13] | D.Bratton,M.Brown,S.M.Howdle,Suspension polymerization of L-Lactide in supercritical carbon dioxide in the presence of a triblock copolymer stabilizer,Macromolecules,36(16),5908(2003) |
| [14] | LI Qianqian,LU Qiwen,LI Lihua,ZHOU Changren,A new preparition process of natural bone material and its characterization,Joural of Biomedical Engineering,24(2),332(2007)(李茜茜,卢绮雯,李立华,周长忍,新型天然骨材料的制备方法及其表征,生物医学工程学杂志,24(2),332(2007)) |
| [15] | ZHANG Run,DENG Zhengxing,LI Lihua,ZHOU Changren,Preparation of porous PLA scaffold materials by surperctitical CO2 fluid technique,Chinese Joural of Materials Reseach,17(6),665(2003)(张润,邓政兴,李立华,周长忍,用超临界CO2制备聚乳酸三维多孔支架材料,材料研究学报,17(6),665(2003)) |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%