以L-聚乳酸为模型体系,超临界CO2为抗溶剂,采用超临界流体抗溶剂法制备聚乳酸微球.考察了压力、温度、溶液浓度、溶液流速、二氯甲烷-丙酮混合溶剂、聚合物分子量等参数对制备微球的形态、粒径及其分布的影响.结果表明,改变工艺参数,可在一定范围内调控微球粒径,所制微球平均粒径0.67～6.64μm,溶液浓度及其流速为主要影响因素;实验条件一定时,采用二氯甲烷-丙酮混合溶剂及强制分散溶液法制备得较小粒径微球.释放度实验结果表明,微球按一级释放方程释药,具缓释效果.
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