系统研究了含有聚乳酸-聚乙二醇-聚乳酸嵌段共聚物（PLA-PEG-PLA）的聚乳酸组织工程支架在模拟体液（SBF）中的降解和生物矿化性能。通过研究可以得到如下结论：随着含有PLA-PEG-PLA共聚物的聚乳酸组织工程支架在模拟体液中浸泡时间的增长,模拟体液的pH值有下降趋势;支架材料的质量有升有降,是降解和矿化作用共同影响的结果。X射线衍射图谱和FT-IR漫反射图谱研究表明,浸在SBF中的支架表面有磷灰石沉积物出现,并且PLA-PEG-PLA共聚物降解速度比PLA快。
Degradable performance and bio-mineralization function of polylactic acid（PLA）-polyethylene glycol（PEG）-PLA/PLA tissue engineering scaffolds in simulated body fluid（SBF） were systematically studied by pH value of SBF,the lost weight ratio of scaffolds,scanning electron microscope（SEM）,X-ray diffraction（XRD） and Fourier transform infrared spectrum（FT-IR） of scaffolds＇ surface.We found that pH value of SBF decreases with the soaking time of PLA-PEG-PLA/PLA tissue engineering scaffolds in SBF decreasing.However,the weight of scaffolds does not always decrease with the time and it is influenced by the process of degradation and by the process of bio-mineralization.The results of XRD and FT-IR measurement show that there appeares the deposition of apatite on the surface of scaffolds and the degradation rate of PLA-PEG-PLA is quicker than that of PLA in SBF.
参考文献
| [1] | Kubies D;Rypacek F;Kovarova J;Lednicky F .Microdomain structure in polylactide-block-poly(ethylene oxide) copolymer films.[J].Biomaterials,2000(5):529-536. |
| [2] | Jain AK;Goyal AK;Mishra N;Vaidya B;Mangal S;Vyas SP .PEG-PLA-PEG block copolymeric nanoparticles for oral immunization against hepatitis B.[J].International Journal of Pharmaceutics,2010(1/2):253-262. |
| [3] | 葛建华,王迎军,郑裕东,朱百家,姜宏伟,南开辉,吴刚.PLA-PEG-PLA嵌段共聚物的合成及研究[J].材料科学与工程学报,2003(06):817-820. |
| [4] | Ning CQ;Zhou Y .In vitro bioactivity of a biocomposite fabricated from HA and Ti powders by powder metallurgy method.[J].Biomaterials,2002(14):2909-2915. |
| [5] | Oliveira JM;Correia RN;Fernandes MH .Effects of Si speciation on the in vitro bioactivity of glasses.[J].Biomaterials,2002(2):371-379. |
| [6] | Kweh SW;Khor KA;Cheang P .An in vitro investigation of plasma sprayed hydroxyapatite (HA) coatings produced with flame-spheroidized feedstock.[J].Biomaterials,2002(3):775-785. |
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