以具有多重响应性的新型单体4-乙酰基丙烯酰乙酸乙酯(AAEA)和N,N'-二甲基丙烯酰胺(DMAA)为原料,采用溶液自由基聚合法合成了具有多重响应性的水凝胶,研究了凝胶的溶胀行为以及在不同离子强度、温度、pH值条件下共聚水凝胶的响应性能.结果表明,随凝胶中AAEA含量的增加,凝胶的溶胀方式由Fick型转变为非Fick型;凝胶对外界离子强度、温度、pH值的变化产生响应,当NaCl浓度约为0.1mol/L时,凝胶的离子响应性出现较大的突变;随温度的升高,凝胶疏水性增大,85℃时凝胶的保水率只有60%;低pH值时,凝胶收缩,随pH值的增大,凝胶内P-AAEA部分解离加剧,静电斥力使凝胶溶胀.
A series of multiple responsive hydrogel of poly(4-acetyl acryloyl ethyl acetate-co-N,N'-dimethylacrylamide) are synthesized by radical solution polymerization.The swelling kinetics of the hydrogels is analyzed by Fick fitting curve.Also,the responsive properties of hydrogels under different conditions(ion intensity,temperature,pH value) are studied.The results reveal that as the content of AAEA increases,the swelling type of hydrogel changes from Fick hydrogel to non-Fick hydrogel.The P(AAEA-co-DMAA) hydrogel has responsive properties to ion intensity,temperature and pH value.Its ionic response changes sharply in 0.1mol/L concentration of NaCl solution.It also expresses hydrophobicity as the temperature rises,its water ration is just 60% under 85℃.The pH value has an important effect on the swelling behavior of P(AAEA-co-DMAA) hydrogel,low pH value will restrain the dissociation of P-AAEA and make hydrogel shrinkage while high pH value will accelerate the dissociation and make hydrogel swollen.So P(AAEA-co-DMAA) hydrogel is a multiple responsive hydrogel.
参考文献
| [1] | 李志军,王振武,宋宏立.智能水凝胶的研究进展[J].化学工业与工程技术,2006(01):6-9. |
| [2] | 刘晓华,王晓工,刘德山.智能型水凝胶结构及响应机理的研究进展[J].化学通报,2000(10):1-6. |
| [3] | 金曼蓉.聚N-烷基丙烯酰胺类凝胶及其温敏特性[J].高分子学报,1995(03):321. |
| [4] | He HY;Cao X;Lee LJ .Design of a novel hydrogel-based intelligent system for controlled drug release[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(3):391-402. |
| [5] | Hutmacher DW. .Scaffolds in tissue engineering bone and cartilage[J].Biomaterials,2000(24 Special Issue SI):2529-2543. |
| [6] | Yuan, CH;Lin, SB;Liu, B;Ke, AR;Quan, ZL .Synthesis and characterization of poly(4-acetyl acryloyl ethyl acetate-co-acrylic acid) novel temperature/pH-sensitive hydrogels[J].Sensors and Actuators, B. Chemical,2009(1):155-161. |
| [7] | Hoffman A S;Dong L C .A novel approach for preparation of pH-sensitive hydrogels for enteric drug[J].Journal of Controlled Release,1991,15(02):141. |
| [8] | Tae G;Wan P .Temperature modulated protein release from pH/temperature-sensitive hydrogels[J].Biomaterials,1999,20:517. |
| [9] | 李鑫.环境响应性凝胶的体积相变行为[J].化学通报（印刷版）,2007(04):292-298. |
| [10] | Zhang XZ.;Yang YY.;Wang FJ.;Chung TS. .Thermosensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with expanded network structures and improved oscillating swelling-deswelling properties[J].Langmuir: The ACS Journal of Surfaces and Colloids,2002(6):2013-2018. |
| [11] | Hiroshi Inomata;Shuichi Goto;Shozaburo Saito .Phase transition of N-substituted acrylamide gels[J].MACROMOLECULES,1990,23(22):4887. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%