为了制备结构和性能满足骨组织工程支架要求的聚乳酸(PLA)多孔支架材料,采用冷冻抽提相分离法,以1,4-二氧六环和水为混合溶剂,聚乙二醇(PEG)为致孔剂,制得一系列PLA多孔支架,探讨了溶剂组成、PLA浓度、PEG添加量对PLA多孔支架结构和性能的影响,结果表明添加PEG有利于形成多孔三维支架,随着PEG含量的增加,孔隙率略有上升,抗压强度下降.随着PLA质量分数的增加,孔隙率明显下降,但抗压强度增大.当混合溶剂中水的含量不超过12%(质量分数),PLA浓度不超过12.5(质量分数),PEG含量不超过20%(质量分数)时,可制得孔隙率和力学性能满足骨组织工程要求的多孔贯穿的支架材料.
参考文献
| [1] | 于斌,申长虹.骨组织工程材料的研究进展[J].医学综述,2006(11):643-645. |
| [2] | Dietmar W. Hutmacher;Thorsten Schantz;Iwan Zein .Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling[J].Journal of biomedical materials research, Part B. Applied biomaterials,2001(2):203-216. |
| [3] | Shin M;Yoshimoto H;Vacanti JP .In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold.[J].Tissue engineering,2004(1/2):33-41. |
| [4] | Joel Reignier;Michel A.Huneault .Preparation of interconnected poly(epsilon-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching[J].Polymer: The International Journal for the Science and Technology of Polymers,2006(13):4703-4717. |
| [5] | Tsinontides SC;Rajniak P;Pham D;Hunke WA;Placek J;Reynolds SD .Freeze drying-principles and practice for successful scale-up to manufacturing.[J].International Journal of Pharmaceutics,2004(1/2):1-16. |
| [6] | Lee KWD;Chan PK;Feng XS .Morphology development and characterization of the phase-separated structure resulting from the thermal-induced phase separation phenomenon in polymer solutions under a temperature gradient[J].Chemical Engineering Science,2004(7):1491-1504. |
| [7] | Harris LD;Kim BS;Mooney DJ .Open pore biodegradable matrices formed with gas foaming.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(3):396-402. |
| [8] | 肖秀峰,黄琼瑜,刘榕芳,佘厚德,林宗琼.纳米羟基磷灰石/聚合物多孔复合支架材料[J].复合材料学报,2008(06):39-46. |
| [9] | 杨凯,季平,滕翠青,徐银宝,余木火.熔融缩聚法制备聚乳酸及其聚己内酯多元醇扩链研究[J].高分子材料科学与工程,2005(02):128-131. |
| [10] | 邓芹英;刘岚;邓慧敏.波谱分析教程[M].北京:科学出版社,2003:44-58. |
| [11] | 吴刚.材料结构表征及应用[M].北京:化学工业出版社,2002:10-28. |
| [12] | Gen-Liang Ji;Bao-Ku Zhu;Zhen-Yu Cui .PVDF porous matrix with controlled microstructure prepared by TIPS process as polymer electrolyte for lithium ion battery[J].Polymer: The International Journal for the Science and Technology of Polymers,2007(21):6415-6425. |
| [13] | 左丹英,徐又一,曾秋霞,龚玉洁.浸没沉淀相转化法制备结晶性聚合物微孔膜的研究进展[J].化学通报（印刷版）,2008(05):336-342. |
| [14] | Strathmann H;Kock K;Amar P et al.[J].Desalination,1975,16(02):179-203. |
| [15] | Zhang Ruiyun;Peter X Ma .[J].Journal of Biomedical Materials Research,1999,45(04):285-293. |
| [16] | 王德平,于睿,黄文旵.生理模拟液中的磷酸钙微晶玻璃的表面变化[J].硅酸盐学报,2004(11):1441-1444. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%