壳聚糖微球是一种典型的生物医用材料,主要应用于药物、杀菌、基因治疗等领域.目前,壳聚糖微球的常用制备方法有化学交联法、离子交换法、复凝聚法、喷雾干燥法和乳化分散法等.分析了壳聚糖微球的主要制备方法,评述了其在药物负载、伤口杀菌、基因治疗等领域的应用.
参考文献
| [1] | Grenha A;Grainger CI;Dailey LA;Seijo B;Martin GP;Remunan-Lopez C;Forbes B .Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro.[J].European journal of pharmaceutical sciences,2007(2):73-84. |
| [2] | Li D H;Liu L M;Tian K L et al.Synthesis,biodegradabili-ty and cytotoxicity of water soluble isobutyl chitosan[J].Carbohydrate Polymers,2007,67(01):40. |
| [3] | Guo Zheng;Bai Shu;Sun Yan .Preparation and characterization of immo-bilized lipase on magnetic hydrophobic micro-spheres[J].Enzyme and Microbial Technology,2003,32:776. |
| [4] | Bai Shu;Guo Zheng;Liu Wei et al.Resolution of menthol by immobilized Candida rugosa lipase on superparamagnetic nanoparticles[J].Food Chemistry,2006,96(01):1. |
| [5] | Badawy Mei;Rabea El;Rogge T M et al.Synthesis and fungicidal activity of new N,O-acyl chitosan derivatives[J].Biomacromolecules,2004,5:589. |
| [6] | Muzzarelli RAA;Guerrieri M;Goteri G;Muzzarelli C;Armeni T;Ghiselli R;Cornelissen M .The biocompatibility of dibutyryl chitin in the context of wound dressings[J].Biomaterials,2005(29):5844-5854. |
| [7] | Balakrishnan B;Mohanty M;Umashankar PR;Jayakrishnan A .Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin[J].Biomaterials,2005(32):6335-6342. |
| [8] | Can Zhang;Yao Cheng;Guowei Qu .Preparation and characterization of galactosylated chitosan coated BSA microspheres containing 5-fluorouracil[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2008(3):390-397. |
| [9] | Genta J;Costantini M .Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan micro-spheres[J].Carbohydrate Polymers,1998,36:81. |
| [10] | 唐振兴,钱俊青,葛立军,何志平.甲壳素/壳聚糖的化学改性及其研究进展[J].杭州化工,2003(04):16-19. |
| [11] | Kang ML;Kang SG;Jiang HL;Shin SW;Lee DY;Ahn JM;Rayamahji N;Park IK;Shin SJ;Cho CS;Yoo HS .In vivo induction of mucosal immune responses by intranasal administration of chitosan microspheres containing Bordetella bronchiseptica DNT.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2006(2):215-220. |
| [12] | Dambies L;Vincent T;Domard A et al.Preparation of chitosan gel beads by ionotropic molybdate gelation[J].Bio-macromolecules,2001,2(04):1198. |
| [13] | Suellen Cadorin Fernandes et al.Biosensor based on laccase immobilized on mi crospheres of chitosan crosslinked with tripolyphosphate[J].Sensors and Actuators B:Chemical,2008,133:202. |
| [14] | Lee JS;Park HJ .Survival of Freeze-Dried Lactobacillus bulgaricus KFRI 673 in Chitosan-Coated Calcium Alginate Microparticles.[J].Journal of Agricultural and Food Chemistry,2004(24):7300-7305. |
| [15] | Vandenberg G W;Drolet C;Scott S L et al.Factors affecting protein release from alginate-chitosan coacervate micro-capsules during prod uction and gastric/intestinal simulation[J].Journal of Controlled Release,2001,77(03):297. |
| [16] | Filipovic Grcic J;Perissutti B;Moneghini M;Voinovich D;Martinac A;Jalsenjak I .Spray-dried carbamazepine-loaded chitosan and HPMC microspheres: preparation and characterisation.[J].Journal of Pharmacy and Pharmacology,2003(7):921-931. |
| [17] | Shantha K L;Harding DRK .Syntheses and characterization and biodistribution of ultrafine chitosan nanoparticles[J].Int J Polym,2002,48:247. |
| [18] | van der Lubben IM;Kersten G;Fretz MM;Beuvery C;Verhoef JC .Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice[J].Vaccine,2003(13/14):1400-1408. |
| [19] | Kockisch S;Rees GD;Young SA;Tsibouklis J;Smart JD .In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions.[J].International Journal of Pharmaceutics,2004(1/2):51-58. |
| [20] | Yawo-Kuo Twu;Yu-Wan Chen;Chao-Ming Shih .Preparation of silver nanoparticles using chitosan suspensions[J].Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems,2008(3):251-257. |
| [21] | Tomoko Oosegi;Hiraku Onishi;Yoshiharu Machida .Novel preparation of enteric-coated chitosan-prednisolone conjugate micro spheres and in vitro evaluation of their potential as a colonic delivery system[J].European Journal of Pharmaceutics and Biopharmaceutics,2008,68:260. |
| [22] | Di Colo G;Zambito Y;Burgalassi S;Nardini I;Saettone MF .Effect of chitosan and of N-carboxymethylchitosan on intraocular penetration of topically applied ofloxacin.[J].International Journal of Pharmaceutics,2004(1/2):37-44. |
| [23] | Chen S;Liu M;Jin S;Wang B .Preparation of ionic-crosslinked chitosan-based gel beads and effect of reaction conditions on drug release behaviors.[J].International Journal of Pharmaceutics,2008(1/2):180-187. |
| [24] | 尹承慧,侯春林,蒋丽霞,顾其胜.羧甲基壳聚糖作为植入可降解缓释微球辅料的实验研究[J].生物医学工程学杂志,2004(03):350-354. |
| [25] | Blanco MD;Gomez C;Olmo R et al.Chitosan microsphere in PLG film as device for cytarabine release[J].International Journal of Pharmaceutics,2001,202(1-2):29. |
| [26] | Portero A;Remunan-lopez C;Criado M T et al.Reacety-la-ted chitosan microsphewes for controlled delivery of anti-mi-crobial agents to the gastric mucosa[J].Journal of Microencapsulation,2002,19(16):797. |
| [27] | Mi FL;Tan YC;Liang HF;Sung HW .In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant.[J].Biomaterials,2002(1):181-191. |
| [28] | Entsar I.Rabea;Mohamed E.-T.Badawy;Christian V.Stevens;Guys Smagghe;Walter Steurbaut .Chitosan as Antimicrobial Agent:Applications and Mode of Action[J].Biomacromolecules,2003(6):1457-1465. |
| [29] | Ye SQ;Wang CY;Liu XX;Tong Z .Deposition temperature effect on release rate of indomethacin microcrystals from microcapsules of layer-by-layer assembled chitosan and alginate multilayer films[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(3):319-328. |
| [30] | Kong M;Chen XG;Liu CS;Liu CG;Meng XH;Yu LJ .Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E-coli[J].Colloids and Surfaces, B. Biointerfaces,2008(2):197-202. |
| [31] | 沈宏亮,王强,钱方,李扬,范列英.左氧氟沙星壳聚糖微球对兔海水浸泡创伤的早期治疗作用[J].解放军医学杂志,2006(03):262-264. |
| [32] | Wang W;Lin SQ;Xiao YC;Huang YD;Tan Y;Cai L;Li XK .Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats[J].Life sciences,2008(3/4):190-204. |
| [33] | Rong Hua Wang;Zhi Gang Hu;Yuyang Liu .Self-Assembled Gold Nanoshells on Biodegradable Chitosan Fibers[J].Biomacromolecules,2006(10):2719-2721. |
| [34] | Li, N;Bai, RB .A novel amine-shielded surface cross-linking of chitosan hydrogel beads for enhanced metal adsorption performance[J].Industrial & Engineering Chemistry Research,2005(17):6692-6700. |
| [35] | 谢英,李明春,辛梅华,张兴松,赵煌.交联壳聚糖微球的制备及吸附性能研究[J].环境科学与技术,2007(11):25-26. |
| [36] | 李志洲,刘军强,刘军海.多孔壳聚糖微球的制备及其在污水处理中的应用[J].化工科技,2008(01):27-31. |
| [37] | 韩德艳,蒋霞,谢长生.交联壳聚糖磁性微球的制备及其对金属离子的吸附性能[J].环境化学,2006(06):748-751. |
| [38] | Characteristics Of Equilibrium, Kinetics Studies For Adsorption Of Hg(Ⅱ), Cu(Ⅱ), And Ni(Ⅱ) Ions By Thiourea-modified Magnetic Chitosan Microspheres[J].Journal of hazardous materials,2009(2/3):995-1002. |
| [39] | 张苏敏,魏永锋,郎惠云.壳聚糖银（Ⅰ）配合物的合成及吸附动力学[J].化学通报（印刷版）,2005(04):296-300. |
| [40] | Tian Jiyuan;Yu Juan;Sun Xiuqin .Chitosan microspheres as candidate plasmid vaccine carrier for oral immunisation of Japanese fiounder (Paralichthys olivaceus)[J].Veterinary Immunology and Immunopathology,2008,126:220. |
| [41] | Julide Akbuga;Suna Ozbas-Turan;Neslihan Erdogan .Plas-mid-DNA loaded chitosan microspheres for in vitro IL-2 expression[J].European Journal of Pharmaceutics and Biopharmaceutics,2004,58:501. |
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