聚乳酸是生物可降解、生物相容性材料,但由于存在亲水性差、缺乏细胞识别位点等缺陷,限制了其在生物医学工程中的应用.模拟细胞与基质相互作用的特点以及细胞外基质的特性,通过表面修饰、本体改性和复合加工的方法在聚乳酸中引入蛋白胶原、活性肽、多糖以及羟基磷灰石等生物活性分子,实现聚乳酸的仿生修饰,能够有效提高聚乳酸材料的生物学功能.综述了利用这些生物活性分子对聚乳酸进行仿生修饰的研究进展.
Polylactides have good biodegradability and biocompatibility, but poor hydrophilicity and lack of cell recognition sites. Their applications in biomedicine engineering have been limited. Mimicking cell-matrix interaction and the properties of extracellular matrix(ECM), bio-inspired modification of polylactides has been achieved by surface modification, bulk modification and composition with bioactive molecules such as collagen, short peptide sequences de-rived from intact ECM proteins, polysaccharides, as well as hydroxyapatite. After the modification, the bio-function of polylactides has been greatly improved. The advances in the modification of polylactides using these bioactive mole-cules are reviewed.
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