包含羟基磷灰石(HA)和磷酸三钙(TCP)的双相磷酸钙陶瓷(BCP)由于其具有良好的降解性能和良好的骨诱导性被看作是骨替代和修复的首选材料.BCP陶瓷的降解性能主要受相成份、孔隙率、材料微观形貌的影响.通过化学共沉淀法制得了成份为60/40(HA/TCP)的双相BCP粉体,通过双氧水发泡法制得了孔隙率分别为40%、60%和80%的多孔双相BCP陶瓷.选用Tris缓冲液浸泡的方法测试材料的体外降解行为.结果显示,孔隙率的改变有效地调控了BCP陶瓷的降解性能.随孔隙率的增加材料的溶出显著加快.高孔隙率材料的快速降解,在体系中释放出相对较高的钙、磷浓度,这可能是其高生物活性的重要影响因素.
参考文献
| [1] | LeGeros R Z;LeGeros J P.Bioceramics 15[M].Zurich:Trans Tech Pulications,2003:3-10. |
| [2] | Bodde E et al.[J].Journal of Biomedical Materials Research Part A,2007,82(03):711-722. |
| [3] | Hing K;Wilson L;Buckland T .[J].Spine Journal,2007,7(04):475-490. |
| [4] | 陈雪宁 .羟基磷灰石陶瓷结构对细胞成骨诱导作用的研究[D].成都:四川大学,2008. |
| [5] | Habibovic P;de Groot D .[J].Journal of Tissue Engineering and Regenerative Medicine,2007,1(01):25-32. |
| [6] | Dvorak MM;Riccardi D .Ca2+ as an extracellular signal in bone.[J].Cell Calcium: The International Interdisciplinary Forum for Research on Calcium,2004(3):249-255. |
| [7] | Honda Y;Anada T;Kamakura S;Nakamura M;Sugawara S;Suzuki O .Elevated extracellular calcium stimulates secretion of bone morphogenetic protein 2 by a macrophage cell line[J].Biochemical and Biophysical Research Communications,2006(3):1155-1160. |
| [8] | Ducheyne P;Radin S;King L .[J].Journal of Biomedical Materials Research,1993,27(01):25-34. |
| [9] | Fulmer MT;Ison IC;Hankermayer CR;Constantz BR;Ross J .Measurements of the solubilities and dissolution rates of several hydroxyapatites.[J].Biomaterials,2002(3):751-755. |
| [10] | Meleti,Z;Shapiro,IM;Adams,CS .Inorganic phosphate induces apoptosis of osteoblast-like cells in culture.[J].Bone,2000(3):359-366. |
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