在镁合金支架材料WE42表面制备了双重可控腐蚀和药物缓释涂层,并对其药物释放性能进行了研究.DSC研究表明紫杉醇均匀分散在PLGA体系中.药物释放实验表明,PLGA可使紫杉醇长期持续释放,突释较弱,释放是由扩散-降解控制.随载药膜中PEG分子量和含量的增加,药物释放率增加.外层明胶涂层能有效降低药物释放率,延长药物释放时间.
参考文献
| [1] | Gu X;Zheng Y;Cheng Y;Zhong S;Xi T .In vitro corrosion and biocompatibility of binary magnesium alloys.[J].Biomaterials,2009(4):484-498. |
| [2] | Ribeiro P A;Gallo R;Antonius J et al.A new expandable intracoronary tantalum (Strecker) stent:Early experimental results and follow-up to twelve months[J].American Heart Journal,1993,125(02):501. |
| [3] | Di Mario C;Griffiths H;Goktekin O;Peeters N;Verbist J;Bosiers M;Deloose K;Heublein B;Rohde R;Kasese V;Ilsley C;Erbel R .Drug-eluting bioabsorbable magnesium stent.[J].Journal of interventional cardiology,2004(6):391-395. |
| [4] | Erne P;Schier M;Resink T J .The road to bioabsorbable stents:Reaching clinical reality[J].Cardiovascular Int Radiology,2006,29(01):11. |
| [5] | Shi Z M;Song G L;Atrens A .The corrosion performance of anodised magnesium alloys[J].Corrosion Science,2006,48(11):3531. |
| [6] | Krishna LR.;Somaraju KRC.;Sundararajan G. .The tribological performance of ultra-hard ceramic composite coatings obtained through microarc oxidation[J].Surface & Coatings Technology,2003(0):484-490. |
| [7] | van der Hoeven B L;Pires N M M;Warda H M et al.Drug-eluting stents:Results,promises and problems[J].International Journal of Cardiology,2005,99(01):9. |
| [8] | Kukreja N;Onuma Y;Daemen J;Serruys PW .The future of drug-eluting stents.[J].Pharmacological research: The official journal of The Italian Pharmacological Society,2008(3):171-180. |
| [9] | Lao LL;Venkatraman SS .Adjustable paclitaxel release kinetics and its efficacy to inhibit smooth muscle cells proliferation[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2008(1):9-14. |
| [10] | Jain RA;Rhodes CT;Railkar AM;Malick AW;Shah NH .Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: effect of various formulation variables.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2000(2):257-262. |
| [11] | 张连鹏,刘敬肖.药物涂层支架的研究进展[J].生物医学工程学杂志,2007(01):235-239. |
| [12] | Siepmann F;Siepmann J;Walther M;MacRae RJ;Bodmeier R .Polymer blends for controlled release coatings[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2008(1):1-15. |
| [13] | Westedt U;Wittmar M;Hellwig M;Hanefeld P;Greiner A;Schaper AK;Kissel T .Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2006(1/2):235-246. |
| [14] | Big A;Cojazzi G;Panzavolta S;Rubini K;Roveri N .Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking.[J].Biomaterials,2001(8):763-768. |
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