使用环糊精和对甲苯磺酰氯制备单-(6-O-对甲苯磺酰基)-β-环糊精,将其与壳聚糖反应后得到可溶于醋酸溶液的壳聚糖同载环糊精,使用一步法与海藻酸钠形成凝胶球(ALg-CDS).用FTIR、UV、TG-DTA、XRD和SEM对产物进行表征,研究了凝胶球在模拟肠液和胃液中的溶胀行为及载药释放性能.结果表明,ALg-CDS凝胶球在肠液中的溶胀率比在胃液中的大;对酮洛芬的吸附过程符合Lagergren二级动力方程,且ALg-CDS凝胶球的载药量(4.19 mg/mg)优于ALg-CS (3.76 mg/mg),ALg-CDS凝胶球比ALg-CS有更好的缓释效果,环糊精的引入提高了载药量和缓释性能.
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