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以灰黄霉素（GRIS）-聚乙烯吡咯烷酮（PVP）体系为例,研究了电喷雾法制备药物-高分子固体分散体,并采用偏光显微镜（POM）、X射线衍射仪（XRD）和差示扫描量热仪（DSC）等方法对体系进行表征。电喷雾法制备得到的微米级固体分散体样品中,体系玻璃化转变温度,很好地符合半经验公式Fox方程,说明GRIS在体系中分散均匀。POM和XRD结果表明,GRIS在样品中的质量分数达50%时,才有少量的GRIS以结晶形式存在于体系中,DSC结果进一步半定量地说明GRIS在制备得到的固体分散体中结晶明显受到抑制。电喷雾法样品用量少,装置和操作简便,是一种制备固体分散体的理想方法。

Griseofulvin（GRIS）-poly（vinyl pyrrolidone） solid dispersion systems were prepared by electro-spraying methods,and characterized by polarized optical microscope（POM）,X-ray diffraction（XRD） and differential scanning calorimeter（DSC）.The results demonstrate that electro-spraying can produce micron-sized particle samples with homogeneous structures,as Tg values of the systems with different drug loading are consistent with predictions from the Fox equation.The electro-spraying also can significantly inhibit GRIS crystallization,since no crystal is observed in freshly prepared solid dispersion until GRIS content up to 50%,and the measured fusion enthalpy of the systems is dramatically lower than the theoretical ones.Compared with the conventionally-used rotary evaporation and spray drying methods,electro-spraying needs very little amount of drugs and is a convenient method for solid dispersion preparation.