以可溶性淀粉为原料,Span80为乳化剂,环氧氯丙烷为交联剂,蓖麻油和甲苯为油相,采用反相乳化交联法合成淀粉微球.由单因素固定变量实验得到合成淀粉微球的最佳实验条件为:淀粉质量分数11％,水相油相体积比1∶20,搅拌速度600r/min.用红外光谱仪进行结构表征,证明环氧氯丙烷和淀粉发生了交联反应.用扫描电子显微镜进行观测,发现淀粉微球粒径范围在40～90μm之间,表面有空隙.研究了不同淀粉质量分数对微球降解速率的影响,结果表明淀粉微球有较好的降解性,且淀粉质量分数越小,降解越慢.淀粉微球的溶血率为0.9％,远小于国家标准5％,证明淀粉微球有较好的血液相容性.
参考文献
| [1] | Mao S;Chen J;Wei Z;Liu H;Bi D .Intranasal administration of melatonin starch microspheres.[J].International Journal of Pharmaceutics,2004(1/2):37-43. |
| [2] | Suzuki M;Masunaga S;Kinashi Y;Nagata K;Sakurai Y;Nakamatsu K;Nishimura Y;Maruhashi A;Ono K .Intra-arterial administration of sodium borocaptate (BSH)/lipiodol emulsion delivers B-10 to liver tumors highly selectively for boron neutron capture therapy: experimental studies in the rat liver model.[J].International Journal of Radiation Oncology, Biology, Physics,2004(1):260-266. |
| [3] | Shiba H;Okamoto T;Futagawa Y;Misawa T;Yanaga K;Ohashi T;Eto Y .Adenovirus vector-mediated gene transfer using degradable starch microspheres for hepatocellular carcinoma in rats.[J].Journal of Surgical Research: Clinical and Laboratory Investigation,2006(2):193-196. |
| [4] | Shitara K;Ikami I;Munakata M;Muto O;Sakata Y .Hepatic arterial infusion of mitomycin C with degradable starch microspheres for unresectable intrahepatic cholangiocarcinoma.[J].Clinical oncology,2008(3):241-246. |
| [5] | Bjork E;Fdman P .Characteriation of degadable starch microspheres a nasal delivery system for drugs[J].International Journal of Pharmaceutics,1990,62:187. |
| [6] | Bjork E;Edman P .Degradable starch microspheres a nasal delivery system for drug delivery system for insulin[J].International Journal of Pharmaceutics,1988,47:233. |
| [7] | 张黎;罗顺德;何文 et al.Pharmacokinetics of aspirin-carrying starch microspheres in rabbit as nasal administration(阿司匹林淀粉微球在兔体内的药动学)[J].中国医院药学杂志,2002,21(04):203. |
| [8] | Vanderhoff J W;Bradford E;Tarkowski H L et al.The particle diameter determination of film-forming latexes by electron microscopy[J].Adv Chem Serises,1962,34:32. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%