为研究碱热处理的钛(AH-Ti)的体内抑菌性能及其机理,以纯钛为对照,将其植入大鼠体内,并注入金黄色葡萄球菌液引起感染.通过测定髓过氧化酶活性评价感染程度,用酶联免疫法测定白蛋白和纤维蛋白原的浓度.结果表明,AH-Ti的细菌感染程度较低,白蛋白和纤维蛋白原浓度也较低.本研究证实了AH-Ti在生理环境下具有一定的抑菌性能,其机理为AH-Ti表面选择性吸附白蛋白而阻止了细菌粘附,从而减轻炎症反应,进而使纤维蛋白原的浓度也较低.
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