壳聚糖/PHB复合缓释微包囊的制备与体外释药评价

材料导报, 2009, 23(12): 109-115.

壳聚糖/PHB复合缓释微包囊的制备与体外释药评价

孟晓荣 ^1, , 黄刚 ^2, , 王琼 ^3, , 杨青翠 ^4, , 张敏 ^5,

1.西安建筑科技大学理学院,西安,710055

2.西安建筑科技大学理学院,西安,710055

3.西安建筑科技大学理学院,西安,710055

4.西安建筑科技大学理学院,西安,710055

5.陕西科技大学化工学院,西安,710021

基金项目: 西安建筑科技大学基础研究基金(JC0822) 国家自然科学基金(50673056) 陕西省教育厅专项项目(08JK315) 西安建筑科技大学人才基金(RC0816)

关键词：壳聚糖 , 三聚磷酸钠 , 聚羟基丁酸酯药物缓释 , 微包囊

Preparation and Drug Release Evaluation in vitro of the Compound Chitosan/PHB Microcapsule with Sustained Release of Drug

用疏水性聚酯PHB外包覆壳聚糖-三聚磷酸钠-阿斯匹林药物缓释体(CPA)制备了壳聚糖/PHB复合缓释微包囊(CPAB),以克服CPA遇酸不稳定的释药特点.用傅立叶红外分光光度计、激光粒度仪、扫描电镜表征了CPAB的组成、粒径及表面形貌.结果显示,CPAB粒径在50～100nm和载药率18.5%时,表面有不均匀的空隙.体外释药评价证实CPAB能有效解决CPA在酸性下的不稳定性,具有长效缓释作用.

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材料期刊网

壳聚糖/PHB复合缓释微包囊的制备与体外释药评价

Preparation and Drug Release Evaluation in vitro of the Compound Chitosan/PHB Microcapsule with Sustained Release of Drug

参考文献