通过采用结构可控的多孔磷酸钙骨水泥(calcium acid phosphate cement,CPC)和钛合金支架材料修复兔颅骨骨缺损,比较了两种修复材料骨环境下的成骨性能.结果显示,与多孔钛合金材料相比,多孔CPC材料表现出了更好的成骨活性.CPC 材料的新生骨量、成骨速率均高于钛合金材料.而且骨吸收重建过程也早于钛合金材料.同时,三维贯通的孔隙结构有利于骨组织的长入,能够在一定程度上克服钛合金材料的应力屏蔽缺陷,使植入体在早期获得良好的固位,从而使界面骨性结合得以顺利进行.
参考文献
| [1] | Damien C J et al.[J].Journal of Applied Biomaterials,1991,2(03):187. |
| [2] | Arrington ED;Smith WJ;Chambers HG;Bucknell AL;Davino NA .Complications of iliac crest bone graft harvesting.[J].Clinical Orthopaedics and Related Research,1996(329):300-309. |
| [3] | Brantigan J W et al.[J].Spine,1993,18(09):1213. |
| [4] | 宋述清,王广义,王宏伟.颅骨修补材料的选择及其评价[J].中国组织工程研究与临床康复,2008(19):3709-3712. |
| [5] | 白如玉,刘福军,卢广宇,王晓东,雷志刚,张寻蒙.几种颅骨修补材料的性能比较[J].中国组织工程研究与临床康复,2008(23):4485-4488. |
| [6] | Vassilis Karageorgiou et al.[J].Biomaterials,2005,26:5474. |
| [7] | Jiaping L et al.[J].Biomaterials,2007,28:4209. |
| [8] | Klein C et al.[J].Biomaterials,1984,5:157. |
| [9] | Case ED;Smith IO;Baumann MJ .Microcracking and porosity in calcium phosphates and the implications for bone tissue engineering[J].Materials Science & Engineering, A. Structural Materials: Properties, Misrostructure and Processing,2005(1/2):246-254. |
| [10] | Hutmaeher D W .[J].Biomaterials,2000,21:2529. |
| [11] | Kokubo T;Takadama H .How useful is SBF in predicting in vivo bone bioactivity?[J].Biomaterials,2006(15):2907-2915. |
| [12] | Farley J R et al.[J].Journal of Bone and Mineral Research,1994,9(04):497. |
| [13] | Maeno S;Niki Y;Matsumoto H;Morioka H;Yatabe T;Funayama A;Toyama Y;Taguchi T;Tanaka J .The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture[J].Biomaterials,2005(23):4847-4855. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%