以羧甲基纤维素(CMC)和壳聚糖(CS)聚合物为原料,采用静电喷雾技术制备了CMC/CS液芯微胶囊.研究了制备条件对微胶囊成型和尺寸的影响,并用激光扫描共聚焦显微镜、扫描电子显微镜和倒置显微镜进行了表征.将四环素与CMC溶液共混,以Al3+-CS作为凝固浴,在电压10 kV、液面距离20 mm、流速10 mL/h的条件下,制备了载药微胶囊.微胶囊的药物包封率随壳聚糖浓度增大而提高,在1.5％时达到99.5％.药物释放实验结果表明CMC/CS液芯微胶囊的释放率与pH有关,控释性能良好.
参考文献
| [1] | Wujie Zhang;Shuting Zhao;Wei Rao .A novel core-shell microcapsule for encapsulation and 3D culture of embryonic stem cells[J].Journal of Materials Chemistry, B. materials for biology and medicine,2013(7):1002-1009. |
| [2] | Jing Zhang;Roger J. Coulston;Samuel T. Jones;Jin Geng;Oren A. Scherman;Chris Abell .One-Step Fabrication of Supramolecular Microcapsules from Microfluidic Droplets[J].Science,2012(Feb.10 TN.6069):690-694. |
| [3] | 于炜婷,刘袖洞,李晓霞,綦文涛,任东文,马小军.壳聚糖溶液pH对载细胞海藻酸钠-壳聚糖微胶囊性能的影响[J].高等学校化学学报,2006(01):182-186. |
| [4] | 刘淑萍,刘娟娟.高压静电喷雾技术在药物微囊制备中的应用进展[J].化工技术与开发,2013(01):21-23. |
| [5] | Deng, R.;Liang, F.;Li, W.;Yang, Z.;Zhu, J. .Reversible transformation of nanostructured polymer particles[J].Macromolecules,2013(17):7012-7017. |
| [6] | Chang, MW;Stride, E;Edirisinghe, M .A New Method for the Preparation of Monoporous Hollow Microspheres[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(7):5115-5121. |
| [7] | Ming-Wei Chang;Eleanor Stride;Mohan Edirisinghe .Controlling the thickness of hollow polymeric microspheres prepared by electrohydrodynamic atomization[J].Journal of the Royal Society Interface,2010(4 Suppl.):451-460. |
| [8] | Ghayempour, S.;Mortazavi, S.M. .Fabrication of micro-nanocapsules by a new electrospraying method using coaxial jets and examination of effective parameters on their production[J].Journal of Electrostatics,2013(4):717-727. |
| [9] | Sasaki, E;Kurayama, F;Ida, JI;Matsuyama, T;Yamamoto, H .Preparation of microcapsules by electrostatic atomization[J].Journal of Electrostatics,2008(5/6):312-318. |
| [10] | 户超,李保国,吴酉芝,应月,董梅.高压静电法制备尿素微胶囊的成囊试验研究[J].农产品加工·学刊,2009(03):78-80,119. |
| [11] | 赵佩瑾,贾方.四环素的微囊化及性能指标的评价[J].中国医药导刊,2008(08):1284-1285,1287. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%