欢迎登录材料期刊网

材料期刊网

中国科学院金属研究所 科学出版社
高级检索
  1. 首页
  2. 期刊
  3. 材料导报
  4. 超临界抗溶剂技术在制备超细微粒中的应用研究进展

材料导报, 2005, 19(z2): 207-210.

超临界抗溶剂技术在制备超细微粒中的应用研究进展

滕新荣 1, , 任杰 2, , 顾书英 3,

1.同济大学材料学院纳米与生物高分子材料研究所,上海,200092

2.同济大学材料学院纳米与生物高分子材料研究所,上海,200092

3.同济大学材料学院纳米与生物高分子材料研究所,上海,200092

基金项目:   上海市纳米科技专项基金(0452nm059;0500236082)  

关键词： 超临界抗溶剂技术 , 超细微粒 , 生物降解聚合物 , 药物

The Application and Development of Preparing Micro-particles Using Supercritical Antisolvent Technology

超临界流体抗溶剂技术可以用于制备微细材料,在高分子、医药、电子和化学工业中都具有广阔的应用前景.综述了超临界抗溶剂技术在制备超细微粒方面的应用研究进展.尤其详细介绍了利用超临界抗溶剂技术在制备生物降解聚合物及药物制剂方面的研究现状.

参考文献

[1] Reverchon E .Supercritical antisolvent precipitation of micro-and nano-particles[J].Journal of Supercritical Fluids,1999,15:1.
[2] Debenedetti P G et al.Formation of protein microparticles by antisolvent precipitation[P].EP:0542314A1,1992.
[3] Yeo S D;Lim G B;Debenedetti P G et al.Formation of microparticulate protein powde′using a supercritical fluid antisolvent[J].Biotechnology and Bioengineering,1993,41:341.
[4] Randolph T W et al.Sub-micrometer-sized biodegradable particles of poly(L-lactic acid)via the gas antisolvent spray precipitation process[J].Biotechnology Progress,1993,9:429.
[5] York P;Hanna M .Salmeterol xinafoate with controlled particle size[P].InternatPatC07C215/60,1994.
[6] Jaarmo S;Rantakyla M;Aaltonen O.Particle tailoring with supercritical fluids:production of amorphous pharmaceutical particles[A].Sendai(Jap),1997:263.
[7] Robertson J;King M B.Recrystallization of organic compounds using near critical carbon dioxide[A].Sendai(Jap),1997:47.
[8] Robertson J;King M B.Problems and potentialities of the gas antisolvent technique[A].CVES Salerno(Ⅰ),1997:365.
[9] David J D;Johnston K P .Polymeric materials formed by precipitation with a compressed fluid antisolvent[J].AICHE Journal,1993,39(01):127.
[10] Yeo S D;Debenedetti P G;Radosz M et al.Supercritical antisolvent process for substituted paralinked aromatic polyamides:phase equilibrium and morphology study[J].Macromolecules,1993,26:6207.
[11] Yeo S D;Debenedetti P G;Radosz M et al.Supercritical antisolvent process for a series of substituted para-linked aromatic polyamides[J].Macromolecules,1995,28:1316.
[12] Johnston K P;Luna-Barcenas G;Dixon D.Polymeric materials by precipitation with a compressed fluid antisolvent[A].INPL,Vandeuvre(Fr),1994:359.
[13] Lunabarcenas G.;Sanchez IC.;Johnston KP.;Kanakia SK. .SEMICRYSTALLINE MICROFIBRILS AND HOLLOW FIBRES BY PRECIPITATION WITH A COMPRESSED-FLUID ANTISOLVENT[J].Polymer: The International Journal for the Science and Technology of Polymers,1995(16):3173-3182.
[14] Steckel H;Thies J et al.Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide[J].International Journal of Pharmaceutics,1997,152:99.
[15] Reverchon E;Porta G .Production of antibiotic micro-and nano-particles by supercritical antisolvent pricipitation[J].Powder Technology,1993,106:23.
[16] Moshashaée S;Bisrat M et al.Supercritical fluid processing of proteins,Ⅰ:lysozyme precipitation from organic solution[J].European Journal of Pharmaceutical Sciences,2000,11:239.
[17] Reverchon E et al.Supercritical antisolvent precipitation of salbutamol microparticles[J].Powder Technology,1999,106:17.
[18] Chattopadhyay P;Gupta R B .Protein nanoparticles formation by supercritical antisolvent with enhanced mass transfer[J].AICHE Journal,2002,48:235.
[19] Bleich J;Muller B W .Aerosol solvent extraction system-a new microparticle production technique[J].International Journal of Pharmaceutics,1993,97:111.
[20] Randolph T W;Randolph A D et al.Sub-micrometer-sized biodegradable particles of poly(L-lactic acid)via the gas antisolvent spray precipitation process[J].Biotechnology Progress,1993,9:429.
[21] Bodmeier R;Wang H et al.Polymeric microspheres prepared by spraying into compressed carbon dioxide[J].Journal of Pharmaceutical Research,1995,13:1211.
[22] Ruchatz F;Muller B W .Thymopentin loaded PLGA microparticles produced by the ASES process[J].Journal of Pharmaceutical Research,1996,13:161.
[23] Saim S;Subramaniam B et al.Particle micronization with compressed gas antisolvents[J].Journal of Pharmaceutical Research,1996,13:S273.
[24] Mawson S.;Johnston KP.;Kanakia S. .COAXIAL NOZZLE FOR CONTROL OF PARTICLE MORPHOLOGY IN PRECIPITATION WITH A COMPRESSED FLUID ANTISOLVENT[J].Journal of Applied Polymer Science,1997(11):2105-2118.
[25] Thies J;Muller B W .Size controlled production of biodegradable microparticles with supercritical gased[J].European Journal of Pharmaceutics and Biopharmaceutics,1998,45:67.
[26] Reverchon E;Porta G D;Rosa I D et al.Supercritical antisolvent micronization of some biopolymers[J].Journal of Supercritical Fluids,2000,18:239.
[27] Breitenbach A.;Kissel T.;Mohr D. .Biodegradable semi-crystalline comb polyesters influence the microsphere production by means of a supercritical fluid extraction technique (ASES)[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2000(1/2):53-68.
[28] Elvassore E;Bertucco A;Caliceti P.Production of Proteinpolymer Micro-capsules by Superciritcal Anti-solvent Techniques[A].,2000:320.
[29] Ghaderi R;Artursson P;Carlfors J .A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in D,L-PLG microparticles using supercritical fluids[J].European Journal of Pharmaceutical Sciences,2000,10:1.
[30] Nicola Elvassore;Alberto Bertucco;Paolo Caliceti .Production of Protein-Loaded Polymeric Microcapsules by Compressed CO_2 in a Mixed Solvent[J].Industrial & Engineering Chemistry Research,2001(3):795-800.
[31] Taki S;Badens E;Charbit G .Controlled release system formed by supercritical anti-solvent coprecipitation of a herbicide and a biodegradable polymer[J].Journal of Supercritical Fluids,2001,21:61.
[32] Wang Yulu .[D].The state university of new Jersy-Newark,US,2004.
[33] Hao J;Whitaker MJ;Wong B;Serhatkulu G;Shakesheff KM;Howdle SM .Plasticization and spraying of poly (DL-lactic acid) using supercritical carbon dioxide: control of particle size.[J].Journal of Pharmaceutical Sciences,2004(4):1083-1090.
[34] Martin J W;Hao Jianyuan et al.The production of proteinloaded microparticles by supercritical fluid enhanced mixing and spraying[J].Journal of Controlled Release,2005,101:85.
[35] 李冬兵,王家炜,杨基础.超临界抗溶剂过程制备扑热息痛微细颗粒的研究[C].第五届全国超临界流体技术学术及应用研讨会论文集,2004:489-493.
[36] 陈岚,张岩,李保国,伍贻文,华泽钊,刘哲鹏,陆伟跃.气体抗溶剂法制备乙基纤维素微球过程的实验研究[J].上海理工大学学报,2004(02):121-125.
[37] 蒋斌波,米娜,陈纪忠.GAS法制备尼莫地平微粒[C].第五届全国超临界流体技术学术及应用研讨会论文集,2004:499-502.
[38] 赵亚平,于文利,蒋思媛.SEDS技术制备难溶性药物纳米颗粒的初步研究[C].第五届全国超临界流体技术学术及应用研讨会论文集,2004:552-555.
[39] 滕新荣;任杰.超临界CO2抗溶剂法制备药物载体聚乳酸微球[J].建筑材料学报
[40] Gao Yong;Mulenda Tshomba Kays;Shi Yi-Feng;Yuan Wei-Kang .Fine particles preparation of Red Lake C Pigment by supercritical fluid[J].The Journal of Supercritical Fluids,1998(1/3):369-374.
[41] Reverchon E;Porta G D;Pace S et al.Supercritical antisolvent precipitation of submicronic particles of superconductor precursors[J].Industrial and Engineering Chemistry Research,1998,37:952.
[42] Reverchon E;Porta G D;Celano C et al.Supercritical antisolvent precipitation:a new technique for preparing submicronic yttrium powders to improve YBCO superconductors[J].Journal of Materials Research,1998,13(02):284.
[43] Reverchon E;Porta G D;Sannino D et al.Supercritical antisolvent precipitation of nanoparticles of a a zinc oxide precursor[J].Powder Technology,1999,102:127.
[44] Gallagher P M;Krukonis V J;Botsaris G D .Gas antisolvent recrystallization:application to particle design[J].AIChE Symposium Series,1991,284(87):96.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
作者相关
文章评分
  • 您的评分：
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%

版权所有©2010中国科学院金属研究所中国科技出版传媒股份有限公司

本系统由北京仁和汇智信息技术有限公司设计开发

技术支持：info@rhhz.net