通过对壳聚糖(CS)进行改性,成功制备了壳聚糖季铵盐(HACC).经过FT-IR、1H NMR表征,证实了其分子结构.采用在仿生溶液中添加CS或HACC的方法,在微弧氧化前后的镁合金样品表面修饰得到4种不同的仿生涂层.利用SEM和XRD对涂层分析表明,仿生矿化后的镁合金表面为含有CaP/CS或CaP/HACC的复合涂层.降解实验表明,微弧氧化后仿生矿化的样品失重率小于微弧氧化前仿生矿化的样品；利用ICP测定释放的镁、铝离子浓度,发现镁离子浓度先升高后降低,铝离子浓度越来越小.抑菌实验结果表明,含有CaP/HACC比含有CaP/CS的复合涂层样品对金黄色葡萄球菌具有更明显的抑菌作用；对于仿生溶液中添加同样浓度的CS或HACC,微弧氧化后比微弧氧化前矿化的样品抑菌率高.比浊法测定显示,4种涂层在4d内均具有不同程度的抑菌效果,微弧氧化后的镁合金样品在添加有HACC的仿生溶液中矿化得到的涂层抑菌率最高.研究说明,改性后的HACC比CS具有更强的抑菌作用；微弧氧化后的样品具有更强的抗腐蚀能力和载药性能.
参考文献
| [1] | Shadanbaz,S.;Dias,G.J. .Calcium phosphate coatings on magnesium alloys for biomedical applications: A review[J].Acta biomaterialia,2012(1):20-30. |
| [2] | 袁广银,张佳,丁文江.可降解医用镁基生物材料的研究进展[J].中国材料进展,2011(02):44-50. |
| [3] | Igor Bezverkhyy;Sophie Schneefeld;Jonathan Skrzypski .Reaction of thiophene with mono- and bimetallic Ni-Co particles supported on γ-Al2O3 and HDS activities of obtained sulfides[J].Applied Catalysis, A. General: An International Journal Devoted to Catalytic Science and Its Applications,2009(1/2):199-204. |
| [4] | Song G .Recent progress in corrosion and protection of magnesium alloys[J].Advances in Engineering Materials,2005,7(07):563-586. |
| [5] | 张雅静,武志林,刘越,张丹.用仿生涂层控制金属镁的降解速率[J].东北大学学报(自然科学版),2010(10):1466-1469. |
| [6] | 郭洁,王欣宇,唐舟,朱伟.通过仿生法在镁合金表面制备羟基磷灰石涂层的研究[J].现代生物医学进展,2009(12):2267-2269. |
| [7] | 褚振华,崔振铎,魏强,杨贤金.Ti合金表面沉积羟基磷灰石-牛血清蛋白生物活性涂层[J].功能材料,2007(11):1881-1883. |
| [8] | Cheng X;Filiaggi M;Roscoe SG .Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy.[J].Biomaterials,2004(23):5395-5403. |
| [9] | Zhao-Xiang Peng;Ling Wang;Lin Du .Adjustment of the antibacterial activity and biocompatibility of hydroxypropyltrimethyl ammonium chloride chitosan by varying the degree of substitution of quaternary ammonium[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2010(2):275-283. |
| [10] | Tan H;Peng Z;Li Q;Xu X;Guo S;Tang T .The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant staphylococcus.[J].Biomaterials,2012(2):365-377. |
| [11] | Sang-Hoon Lim;Samuel M.Hudson .Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group[J].Carbohydrate research,2004(2):313-319. |
| [12] | Chung YC;Chen CY .Antibacterial characteristics and activity of acid-soluble chitosan[J].Bioresource Technology: Biomass, Bioenergy, Biowastes, Conversion Technologies, Biotransformations, Production Technologies,2008(8):2806-2814. |
| [13] | Napanporn Vallapa;Oraphan Wiarachai;Nuttha Thongchul .Enhancing antibacterial activity of chitosan surface by heterogeneous quaternization[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(2):868-875. |
| [14] | Ji, QX;Zhong, DY;Lu, R;Zhang, WQ;Deng, J;Chen, XG .In vitro evaluation of the biomedical properties of chitosan and quaternized chitosan for dental applications[J].Carbohydrate research,2009(11):1297-1302. |
| [15] | Zhang R F;Shan D Y;Han E H .Development of a microarc oxidation process to improve corrosion resistance on AZ91HP magnesium alloy[J].Transactions of Nonferrous Metals Society of China,2006,16:685-688. |
| [16] | Jukka Holappa;Martha Hjalmarsdottir;Mar Masson .Antimicrobial activity of chitosan N-betainates[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2006(1):114-118. |
| [17] | Cheng S;Wei D Q;Zhou Y .Mechanical and corrosion resistance of hydrophilic sphene/titania composite coatings on titanium and deposition and release of cefazolin sodium/chitosan films[J].Applied Surface Science,2011,257:2657-2664. |
| [18] | Robinson DA;Griffith RW;Shechtman D;Evans RB;Conzemius MG .In vitro antibacterial properties of magnesium metal against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.[J].Acta biomaterialia,2010(5):1869-1877. |
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