本文采用冷冻爆破法,将壳聚糖在LiOH/尿素溶液中溶胀,-60℃冷冻结冰,解冻搅拌后得到澄清壳聚糖溶液.壳聚糖碱溶液在硫酸/乙醇凝固浴中反相沉析,得到壳聚糖凝胶膜.此碱性溶剂体系法能避免壳聚糖降解,提高力学强度.力学测试结果表明,壳聚糖水凝胶膜拉伸强度为2.28MPa,最大拉伸应变(ε)达到226％.SEM观测到水凝胶微观结构类似蜂窝状,孔径均匀、致密,大小分布为50nm～5μm; XRD分析结果表明,碱溶液体系处理后壳聚糖晶型由α型转变成β型,结晶度降低.致密的结构和低结晶度是壳聚糖凝胶膜透明性和力学强度提高的重要原因.该性能优异的壳聚糖凝胶膜在关节软骨、创口敷料等方面有良好的应用前景.
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