纳米材料的毒性效应研究是纳米技术的一门重要学科,主要研究纳米物质和生物体及环境的相互作用,着重研究纳米物质的物理化学特性等与生物学毒性效应之间的关系.分析了纳米材料毒性研究的特点及产生的背景,以及纳米材料的暴露途径和对生物体及环境的潜在威胁;探讨了纳米材料产生毒性效应的几种可能机制;介绍了国内外几种典型的纳米材料毒性研究情况;展望了今后研究中需重点解决的问题,如加强分子水平上纳米材料毒性效应的研究、构建预测纳米材料潜在影响的理论模型等.
参考文献
[1] | Ermie Hood .Nanotechnology:Think before we leap[J].Environmental Health Perspectives,2004,112:A740. |
[2] | Oberdorster G;Finkelstein J N;Johnston C .Acute pulmo nary effects of ultrafine particles in rats and mice[J].Research Report/Health Effects Institute,2000,96:5. |
[3] | 汪冰,丰伟悦,赵宇亮,邢更妹,柴之芳,王海芳,贾光.纳米材料生物效应及其毒理学研究进展[J].中国科学B辑,2005(01):1-10. |
[4] | 韦东远,龚钟明,张俊祥.关于我国纳米生物效应与安全性研究的思考[J].创新科技,2008(06):54-55. |
[5] | 李卫华,市原学,李洁斐,王强毅,顾祖维,丁训诚.纳米材料的毒理学和安全性[J].环境与职业医学,2006(05):430-434. |
[6] | 白茹,王雯,金星龙,宋文华.纳米材料生物安全性研究进展[J].环境与健康杂志,2007(01):59-61. |
[7] | 赵春芳.纳米材料的环境风险[J].化学教学,2005(05):42-43. |
[8] | 王翔,贾光,王生,常元勋.001 纳米材料与健康效应关系的研究进展[J].国外医学(卫生学分册),2005(01):1-6. |
[9] | Li N;Sioutas C;Cho A et al.Uhrafine particulate pollutants induce oxidative stress and mitoehondrial damage[J].Environmental Health Perspectives,2003,111:455. |
[10] | Austin M. Derfus;Warren C. W. Chan;Sangeeta N. Bhatia .Probing the Cytotoxicity of Semiconductor Quantum Dots[J].Nano letters,2004(1):11-18. |
[11] | Zhou YM;Zhong CY;Kennedy IM;Leppert VJ;Pinkerton KE .Oxidative stress and NFkappaB activation in the lungs of rats: a synergistic interaction between soot and iron particles.[J].Toxicology and Applied Pharmacology,2003(2):157-169. |
[12] | Hughes L S;Cass G R;Gone J et al.Physical and chemical characterization of atmospheric uhrafine particles in the Los Angeles area[J].Environmental Science and Technology,1998,32:1153. |
[13] | Kulmala M .Formation and growth rates of uhrafine atmospheric panicles:A review of observations[J].Journal of Aerosol Science,2004,35:143. |
[14] | Christie M S;Andre M G;Kevin D A .Nano C60 cytotoxicity is due to lipid peroxidation action[J].Biomaterials,2005,26:7587. |
[15] | Christie M.Sayes;John D.Fortner;Wenh Guo .The Differential Cytotoxicity of Water-Soluble Fullerenes[J].Nano letters,2004(10):1881-1888. |
[16] | Moiler W;Hofer T;Ziesenis A et al.Uhrafine particles cause cytoskeletal dysfunction in macropbages[J].Toxicology and Applied Pharmacology,2002,182:197. |
[17] | 王娜,程炯佳,金焰,姚开安,毕树平.人工纳米材料的生物效应及其对生态环境的影响[J].生态毒理学报,2007(03):252-264. |
[18] | Dreher K L .Health and environmental impact of nanotechnology:Toxicological assesment of manufactured nanoparticles[J].Toxicological Sciences,2004,77(01):3. |
[19] | 陆荔,马明,张宇,唐萌,顾宁.纳米材料生物安全性研究进展[J].东南大学学报(自然科学版),2004(05):711-714. |
[20] | Lam CW;James JT;McCluskey R;Hunter RL .Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation.[J].Toxicological sciences: An official journal of the Society of Toxicology,2004(1):126-134. |
[21] | Warheit D B;Laurence B R;Reed K L.Pulmonarytoxicity-screening studies with single-wall carbon nanotubes[A].New Orleans,LA,USA,2003:23. |
[22] | Ziady AG;Gedeon CR;Muhammad O;Stillwell V;Oette SM;Fink TL;Quan W;Kowalczyk TH;Hyatt SL;Payne J;Peischl A;Seng JE;Moen RC;Cooper MJ;Davis PB .Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung.[J].Molecular therapy: the journal of the American Society of Gene Therapy,2003(6):948-956. |
[23] | 马明,朱毅,张宇,张东生,唐祖明,张海黔,顾宁.四氧化三铁纳米粒子与癌细胞相互作用的初步研究[J].东南大学学报(自然科学版),2003(02):205-207. |
[24] | 李杜,何晓晓,王柯敏,何春梅.无机硅壳类纳米颗粒对细胞的毒性检测[J].湖南大学学报(自然科学版),2002(06):1-6. |
[25] | 贾元宏,张淑青,张学庆,王玲.一种纳米材料抑菌效果及毒性试验观察[J].预防医学文献信息,2002(06):737-737. |
[26] | Richard D Handy;yon der Kammer Frank;Jamie R Lead et al.The ecotoxicology and chemistry of manufactured nanoparticles[J].Ecotoxicology,2008,17:287. |
[27] | Andrew D.Maynard .Nanotechnology:assessing the risks[J].Nano Today,2006(2):22-33. |
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