以L-乳酸(LLA)和壳聚糖(CS)为原料,4-(二甲胺基)吡啶(DMAP)及N,N'-二环己基碳酰亚胺(DOC)为催化剂在室温下,通过直接缩合方法制备了聚乳酸-壳聚糖接枝共聚物(PLLA-CS).采用IR、1H-NMR及薄板毛细渗透法对其结构进行了表征.探讨了原料配比、催化剂用量、LLA的二氯甲烷溶液浓度、反应时间等对共聚物收率和亲水性的影响.得到最佳工艺条件:-NH2:LLA为1:15,DCC:LLA为1:1,LLA的二氯甲烷溶液浓度为1.88 mol/L,反应时间为24 h.此方法合成路线短、反应条件温和.聚乳酸-壳聚糖接枝共聚物具有良好的细胞亲和性,有望成为一类优良的组织工程材料.
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