以介孔二氧化硅MCM-41作为药物载体吸附布洛芬,通过与聚乙烯醇水溶液混合、交联制备了交联聚乙烯醇形状记忆复合材料.采用高强度聚焦超声作为刺激手段,研究了交联聚乙烯醇复合材料的形状记忆性能和药物释放性能.结果表明,在高强度聚焦超声作用下,交联聚乙烯醇形状记忆复合材料具有良好的形状记忆性能,形状回复率随着超声时间的延长逐渐增大直至达到平衡状态,形状回复率可达～90％,且最终回复率随着SiO2/ibuprofen载入量的增大明显下降;同时,聚焦超声实现了布洛芬的可控周期性释放过程,调节聚焦超声时间和功率可以调节布洛芬的释放量;另外,SiO2/ibuprofen的加入提高了聚乙烯醇复合材料的热稳定性.
参考文献
| [1] | Guo Li;Guoxia Fei;Hesheng Xia, .Spatial and temporal control of shape memory polymers and simultaneous drug release using high intensity focused ultrasound[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2012(16):7692-7696. |
| [2] | Han, J.;Fei, G.;Li, G.;Xia, H. .High intensity focused ultrasound triggered shape memory and drug release from biodegradable polyurethane[J].Macromolecular chemistry and physics,2013(11):1195-1203. |
| [3] | Du, H.;Zhang, J. .Solvent induced shape recovery of shape memory polymer based on chemically cross-linked poly(vinyl alcohol)[J].Soft matter,2010(14):3370-3376. |
| [4] | Haiyan Du;Junhua Zhang .Shape memory polymer based on chemically cross-linked poly(vinyl alcohol) containing a small number of water molecules[J].Colloid and polymer science,2010(1):15-24. |
| [5] | LIN J.R.;CHEN L.W. .Study on Shape-Memory Behavior of Polyether-Based Polyurethanes.I.Influence of the Hard-Segment Content[J].Journal of Applied Polymer Science,1998(8):1563-1574. |
| [6] | LIN J.R.;CHEN L.W. .Study on Shape-Memory Behavior of Polyether-Based Polyurethanes.II.Influence of Soft-Segment Molecular Weight[J].Journal of Applied Polymer Science,1998(8):1575-1586. |
| [7] | C.Li;H.Qin;P.T.Mather .Review of progress in shape-memory polymers[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2007(16):1543-1558. |
| [8] | Prokopowicz,M .Correlation between physicochemical properties of doxorubicin-loaded silica/polydimethylsiloxane xerogel and in vitro release of drug.[J].Acta Biomaterialia,2009(1):193-207. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%