聚异丙基丙烯酰胺是一类具有温度敏感性的智能高分子材料,其特性在生物医学领域加以利用,可基本满足生物医学用材料的要求,具有广阔的应用前景.从聚合物角度综述了聚异丙基丙烯酰胺近几年在组织工程、药物释放体系、生物分离等领域的研究进展.
参考文献
[1] | Lysaght,MJ;O'Loughlin,JA .Demographic scope and economic magnitude of contemporary organ replacement therapies.[J].American Society for Artificial Internal Organs Journal,2000(5):515-521. |
[2] | 马光辉;苏志国.新型高分子材料[M].北京:化学工业出版社,2003 |
[3] | 魏中国;杨大智 .智能材料及自适应结构[J].高技术通讯,1993,3(06):37. |
[4] | Hirotsu S .Coexistence of phase and the nature of first-order phase transition in poly (N-isopropylacrylamide) gels[J].Advances in Polymer Science,1993,110:1. |
[5] | Schild H G .Poly (N-isopropylacrylamide): experiment, theory and application[J].Progress in Polymer Science,1992,17:163. |
[6] | 姚康德;尹玉姬.组织工程相关生物材料[M].北京:化学工业出版社,2003 |
[7] | Yannas I V;Burke J F .Design of an artificial skin. I. Basic design principles[J].Journal of Biomedical Materials Research,1980,14:65. |
[8] | Yannas I V;Burke J F;Gordon P L et al.Design of an artificial skin. Ⅱ. Control of chemical composition[J].Journal of Biomedical Materials Research,1980,14:107. |
[9] | Dagalakis N;Flink J;Stasikelis P et al.Design of an artificial skin. Part Ⅲ. Control of pore structure[J].Journal of Biomedical Materials Research,1980,14:511. |
[10] | Langer R;Vacanti J P .Tissue engineering[J].Science,1993,260:920. |
[11] | Hutmacher DW .Scaffolds in tissue engineering bone and cartilage.[J].Biomaterials,2000(24):2529-2543. |
[12] | 岡野光夫.日本バイオマテリアル学会特别シンポジウム资料集[M].东京:きようだい堂,2001:1. |
[13] | Kwon O H;Kikuchi A;Yamato M et al.Rapid cell sheet detachment from poly ( N-isopropylacrylamide )-grafted porous cell culture membranes[J].Journal of Biomedical Materials Research,2001,55:20. |
[14] | Yamada N;Okano T;Sakai H et al.Thermo-responsive polymeric surfaces, control of attachment and detachment of cultured cells[J].Macromolecular Rapid Communications,1990,11:571. |
[15] | 和雅之;懬漱志弘;播元政美 等.人工材料を用いた细胞のマ二ピエし-ミヨン二二细胞シ-ト工学の創成[J].蛋白质·核酸·酵素,2000,45:2156. |
[16] | Yamato M;Konno C;Kushida A et al.Release of adsorbed firbronectin from temperature-responsive culture surfaces requires cellular activity[J].Biomaterials,2002,21:981. |
[17] | Kushida A;Yamato M;Konno C;Kikuchi A;Sakurai Y;Okano T .Temperature-responsive culture dishes allow nonenzymatic harvest of differentiated Madin-Darby canine kidney (MDCK) cell sheets.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2000(2):216-223. |
[18] | Shimizu T;Yamato M;Akutsu T et al.Electrically communicating three-dimensional cardiac tissue mimic fabricated by layered cultured cardiomyocyte sheets[J].Journal of Biomedical Materials Research,2002,60:110. |
[19] | Yamato M;Konno C;Utsumi M;Kikuchi A;Okano T .Thermally responsive polymer-grafted surfaces facilitate patterned cell seeding and co-culture.[J].Biomaterials,2002(2):561-567. |
[20] | Nandkumar MA;Yamato M;Kushida A;Konno C;Hirose M;Kikuchi A;Okano T .Two-dimensional cell sheet manipulation of heterotypically co-cultured lung cells utilizing temperature-responsive culture dishes results in long-term maintenance of differentiated epithelial cell functions.[J].Biomaterials,2002(4):1121-1130. |
[21] | Kikuchi A;Okuhare M;Karikusa F et al.Two-dimensional manipulation of confluently cultured vascular endothelial cells using temperature-responsive poly ( N-isopropylacrylamide )-grafted surfaces[J].Journal of Biomaterials Science-Polymer Edition,1998,9:1331. |
[22] | Yamato M;Utsumi M;Kushida A;Konno C;Kikuchi A;Okano T .Thermo-responsive culture dishes allow the intact harvest of multilayered keratinocyte sheets without dispase by reducing temperature.[J].Tissue engineering,2001(4):473-480. |
[23] | Shimizu T;Yamato M;Isoi Y et al.Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces[J].Circulation Research,2002,90:40. |
[24] | Harimoto M;Yamato M;Hirose M et al.Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto monolayer hepatocytes utilizing temperature-responsive culture dishes[J].Journal of Biomedical Materials Research,2002,62:464. |
[25] | Shimizu T;Yamato M;Kikuchi A;Okano T .Two-dimensional manipulation of cardiac myocyte sheets utilizing temperature-responsive culture dishes augments the pulsatile amplitude.[J].Tissue engineering,2001(2):141-151. |
[26] | Kwon OH.;Kikuchi A.;Yamato M.;Okano T. .Accelerated cell sheet recovery by co-grafting of PEG with PIPAAm onto porous cell culture membranes[J].Biomaterials,2003(7):1223-1232. |
[27] | Stile Ranee A.;Healy Kevin E.;Burghardt Wesley R. .Synthesis and characterization of injectable poly(N-isopropylacrylamide)-based hydrogels that support tissue formation in vitro[J].Macromolecules,1999(22):7370-7379. |
[28] | Cammas S;Suzuki K;Sone C et al.Thermo-responsive polymer nanoparticles with a core-shell micelle structure as sitespecific drug carriers[J].Journal of Controlled Release,1997,48:157. |
[29] | Jeong B;Kim SW;Bae YH .Thermosensitive sol-gel reversible hydrogels.[J].Advanced drug delivery reviews,2002(1):37-51. |
[30] | Uludag H;Norrie B;Kousinioris N;Gao TJ .Engineering temperature-sensitive poly(N-isopropylacrylamide) polymers ascarriers of therapeutic proteins[J].Biotechnology and Bioengineering,2001(6):510-521. |
[31] | Dong L C;Hoffman A S .A novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery[J].Journal of Controlled Release,1991,15:141. |
[32] | 岡野光夫 .インテリジエト材料とその生物医学领域への应用[J].海外高分子研究,1997,43(09):72. |
[33] | Zhang XZ;Wu DQ;Chu CC .Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels.[J].Biomaterials,2004(17):3793-3805. |
[34] | Nakayamaa H;Kaetsub I et al.Radiation curing of intelligent coating for controlled release and permeation[J].Radiation Physics and Chemistry,2002,63:521. |
[35] | Kawaguchi H;Fujimoto K;Kasuya Y .Hydrogel microspheres Ⅲ[J].Temperature-dependent absorption of proteins on poly-Nisopropylacry lamide hydrogel microspheres Colloid Polym Sci,1992,270:53. |
[36] | Choi S H;Yoon J J;Park T G .Galactosylated poly(N-isopropylacrylamide) hydrogel submicrometer particles for spectific cellular uptake within hepatocytes[J].Journal of Colloid and Interface Science,2002,251:57. |
[37] | 琚正川,陈洁,肖智成.P(NIPAM-DADMAC)微凝胶的合成、表征及药物释放[J].同济大学学报(自然科学版),2003(10):1256-1260. |
[38] | Okahata Y;Noguchi H;Seki T .Thermoselective permeation from a polymer-grafted capsule membrane[J].Macromolecules,1986,19:493. |
[39] | Hiroo I;Masaga O;Yoshikimi U et al.Preparation of temperature-sensitive membranes by graft polymerization onto a porous membrane[J].Journal of Membrane Science,1991,55:119. |
[40] | 竹岡敬和;渡边正義 .分子認識ゲルの可能性[J].化学(日本),1998,53:74. |
[41] | Suzuki A;Tanaka T.Phase transition in polymer gels induced by visible light[J].NATURE,1990(346):345. |
[42] | 吉田亮;高橘利和;山口智彦ろ .自律振动ゲル[J].化学と工業,1997,50(07):1014. |
[43] | 黄月文,罗宣干,卓仁禧.蜗牛酶在聚(N-异丙基丙烯酰胺)中的固定化及应用[J].功能高分子学报,1996(04):523-531. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%