通过原位共聚制备了一种新型可降解α-磷酸钙/多元氨基酸共聚物复合材料,采用FTIR、XRD、SEM和模拟体液浸泡法对其性能进行表征.结果表明:该复合材料由具有聚酰胺结构的氨基酸共聚物和α-磷酸钙组成;该材料初期降解较快,浸泡1周后材料失重6.8%,12周后材料总失重为20.1%;降解产物无强酸性物质,pH在6.6～7.0范围内;材料吸水率在11%左右,浸泡过程中无明显变化.扫描电镜分析表明,浸泡2周后,材料表面变得光滑,并有少量沉积物生成;随着浸泡时间增加,表面沉积物逐渐增加,12周时大量的沉积物几乎覆盖了样品全部表面.XRD分析表明沉积物为羟基磷灰石,这说明材料具有良好的生物活性;浸泡12周后,去除样品表面沉积物,用XRD分析其直接接触液体的表面和未接触液体的内部表面,发现材料表面的两相结晶峰宽化,而材料内部无显著变化,表明该复合材料可能是一种表面腐蚀降解材料.该新型复合材料可望在骨修复和组织工程方面得到广泛应用.
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