对医用镁可降解高分子基复合材料表面改性技术进行了探索研究，以提高镁在生理环境下的耐蚀性及其表面的生物相容性。采用环氧氯丙烷-丙酮混合溶剂在高纯镁上制备了 L-聚乳酸(PLLA)涂层，再分别以MgO和Mg(OH)2为增强相，制备了PLLA基复合涂层。使用扫描电镜、耐蚀性快速检测、涂层/基体结合力测试、电化学动电位极化曲线测量以及体外生物降解行为研究对涂层进行综合分析。结果表明，适量 MgO 或Mg(OH)2增强相的添加均能显著提高PLLA涂层在Hank’s模拟体液中的降解防护性能，并有利于降低 PLLA 生物降解所产生的酸化效应。
The surface modification of magnesium alloys by bio-degradable polymer matrix composites for biomedical applications was studied to improve both corrosion resistance and surface biocompatibility of magnesium under physiological conditions. A poly(L-lactic acid) (PLLA) coating was formed on high-purity magnesium substrate with epichlorohydrin and acetone as solvent, and two PLLA matrix composite coatings were prepared with MgO and Mg(OH)2 as reinforcement respectively. The comprehensive performances of the coatings were evaluated by scanning electron microscopy, rapid corrosion resistance test, coating/substrate adhesion test, potentiodynamic polarization measurement, and in vitro biodegradation behavior studies. The results showed that adding an appropriate amount of MgO or Mg(OH)2 as reinforcement can improve the resistance of PLLA coating to degradation in Hank’s simulated body fluid, and reduce the acidification during the dissolution of PLLA.
参考文献
| [1] | Bruno Zberg;Peter J. Uggowitzer;Jorg F. Loffler .MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants[J].Nature materials,2009(11):887-891. |
| [2] | J.E. Gray;B. Luan .Protective coatings on magnesium and its alloys-a critical review[J].Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics,2002(1/2):88-113. |
| [3] | 浦素云.金属植入材料及其腐蚀[M].北京:北京航空航天大学出版社,1990:29. |
| [4] | 李智,周世杰,赵炯.生物医用纯镁的腐蚀性能研究[J].热加工工艺,2012(16):53-56. |
| [5] | 盛敏刚,张金花,李延红.环境友好新型聚乳酸复合材料的研究及应用[J].资源开发与市场,2007(11):1012-1014,1028. |
| [6] | Bunger CM;Grabow N;Sternberg K;Kroger C;Ketner L;Schmitz KP;Kreutzer HJ;Ince H;Nienaber CA;Klar E;Schareck W .Sirolimus-eluting biodegradable poly-L-lactide stent for peripheral vascular application: a preliminary study in porcine carotid arteries.[J].Journal of Surgical Research: Clinical and Laboratory Investigation,2007(1):77-82. |
| [7] | 许春姣,郭峰,高清平,吴颖芳,翦新春,彭解英.骨髓基质干细胞与黄芪-壳聚糖/聚乳酸支架对犬牙周骨缺损再生的影响[J].中南大学学报（医学版）,2006(04):512-517. |
| [8] | Isotalo T;Alarakkola E;Talja M;Tammela TL;Valimaa T;Tormala P .Biocompatibility testing of a new bioabsorbable X-ray positive SR-PLA 96/4 urethral stent.[J].The Journal of Urology,1999(5):1764-1767. |
| [9] | 华南理工大学 .一种材料耐蚀性快速检测方法[P].CN,102841050,2012-12-26. |
| [10] | 马晓妍 .聚乳酸及其共聚物的制备和降解性能研究[D].北京化工大学,2004. |
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