{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":3,"startPagecode":1},"records":[{"abstractinfo":"以生物相容性好、价格低廉的海藻酸钠(ALG)为聚阴离子芯材,通过静电液滴装置制备了平均粒径在290μm左右、球形度好、表面光洁的海藻酸钙胶珠;再将生物可降解、具有介入治疗作用的聚精氨酸(PLA)与聚组氨酸(PLH)的混合物作为聚阳离子壁材,在海藻酸钙胶珠表面覆上一层高分子聚合膜以制备聚氨基酸复合微胶囊;并以牛血红蛋白Hb为药物模型,对微胶囊的控制释放性能进行了考察并将其初步应用于体外模拟口服给药.结果表明:聚氨基酸复合微胶囊在前0.5 h的累积释放量均低于40%,溶出结柬时累积释放量均达到80%以上;ALG/(PLA-PLH)复合微胶囊和ALG/PLH微胶囊的药物释放速率均低于ALG/PLA微胶囊;于10min成膜时间内制备的微胶囊具有较高的载药量、包封率和缓释性能;以pH 4.6 HAc-NaAc缓冲液为成膜溶媒制备的微胶囊,Hb持续释放时间和残留量均高于蒸馏水组;前2h在模拟胃液的pH 1.2 HCI溶媒中累计释放的Hb不超过10%且绝大部分是在模拟肠液环境即pH 6.8PBS溶媒中释放的;壳聚糖的引人能在一定程度上延长药物释放时间.聚氨基酸复合微胶囊具备一定的缓释性、pH响应性和生理黏附性,有望成为一种口服给药系统用药物载体.","authors":[{"authorName":"蓝琪","id":"22b4db27-4714-4bf8-8912-109df1ce8935","originalAuthorName":"蓝琪"},{"authorName":"<span style=\"color:red\">陈</span><span style=\"color:red\">宝剑</span>","id":"f77017e2-21fc-4fa4-b0b6-19497e4c44d7","originalAuthorName":"陈宝剑"},{"authorName":"王士斌","id":"1eca6d39-6a87-4c33-9eb2-a2c513daa168","originalAuthorName":"王士斌"},{"authorName":"<span style=\"color:red\">陈</span>梅英","id":"6e60119f-44b8-463a-82cc-b8d18e185a34","originalAuthorName":"陈梅英"},{"authorName":"侯越","id":"52e61818-df9d-49bb-bd4f-d19973ee483f","originalAuthorName":"侯越"}],"doi":"","fpage":"33","id":"017fccd1-c10d-4547-ab95-3dac6eeef032","issue":"6","journal":{"abbrevTitle":"FHCLXB","coverImgSrc":"journal/img/cover/FHCLXB.jpg","id":"26","issnPpub":"1000-3851","publisherId":"FHCLXB","title":"复合材料学报"},"keywords":[{"id":"e36442ab-cca0-4aed-82fc-1cde5818f62b","keyword":"聚精氨酸","originalKeyword":"聚精氨酸"},{"id":"e1470877-4330-4d2f-b975-5f87ceb94e9a","keyword":"聚组氨酸","originalKeyword":"聚组氨酸"},{"id":"f5e7d00a-2639-4342-b043-3fdbdab40ff6","keyword":"海藻酸钙","originalKeyword":"海藻酸钙"},{"id":"5390ed55-d558-44a6-9309-1bfa6b90dd3b","keyword":"微胶囊","originalKeyword":"微胶囊"},{"id":"89bb0d39-cf41-4602-9274-58eac1c9d764","keyword":"药物控制释放","originalKeyword":"药物控制释放"}],"language":"zh","publisherId":"fhclxb200806007","title":"聚氨基酸复合微胶囊对Hb的控制释放","volume":"25","year":"2008"},{"abstractinfo":"以能量为1.5 MeV/u，剂量分别为500，750，1000，1250，1500 Gy的电子束对1，2，4，6，8年等5种年份浓香型白酒进行辐照处理；扫描各酒样200～400 nm波段的紫外光谱，根据紫外光谱图的差异，计算了280～300 nm波段的光谱曲线相似度，分析光谱曲线变化规律。结果表明，对于前4种白酒，对照样与辐照样光谱曲线相似度值越小，催<span style=\"color:red\">陈</span>效果越好；白酒存放时间越久，酒体风格转向老熟所需剂量越小，越容易达到最佳催<span style=\"color:red\">陈</span>效果；对于8年白酒，辐照剂量超过750 Gy后，白酒体系动态平衡被打破，各单体物质增加，出现返生现象。因此，电子束辐照技术对低年份浓香型白酒催<span style=\"color:red\">陈</span>效果显著，是一种先进、高效的催<span style=\"color:red\">陈</span>方法。","authors":[{"authorName":"张苗苗","id":"16f2bee9-e276-4f55-95b1-9e627a4ac276","originalAuthorName":"张苗苗"},{"authorName":"陆栋","id":"6bd2c6ff-fa0f-4deb-9553-bfa0e40d3ab7","originalAuthorName":"陆栋"},{"authorName":"曹国珍","id":"ad44f083-8f23-4d8d-a41c-b6321e181155","originalAuthorName":"曹国珍"},{"authorName":"刘敬","id":"980de600-54b3-4c10-b2b1-7d36c88bd704","originalAuthorName":"刘敬"},{"authorName":"金文杰","id":"9d97782b-4400-438f-aa1a-efaa2ae74455","originalAuthorName":"金文杰"},{"authorName":"王菊芳","id":"7a171c96-4419-441c-8118-cabb35cc1b2c","originalAuthorName":"王菊芳"},{"authorName":"李文建","id":"db0225a5-b939-440c-a47d-2daa37f339b7","originalAuthorName":"李文建"}],"doi":"10.11804/NuclPhysRev.31.02.218","fpage":"218","id":"be399f10-d5ab-444a-9853-693337e4845a","issue":"2","journal":{"abbrevTitle":"YZHWLPL","coverImgSrc":"journal/img/cover/YZHWLPL.jpg","id":"78","issnPpub":"1007-4627","publisherId":"YZHWLPL","title":"原子核物理评论   "},"keywords":[{"id":"d27824cd-9a7d-40d6-ade5-08e57f3651e9","keyword":"白酒","originalKeyword":"白酒"},{"id":"a87d8a5f-52c5-438d-9818-ac05aa030ecd","keyword":"电子束","originalKeyword":"电子束"},{"id":"59b3d998-0774-4358-b00a-6ad942d1d4f2","keyword":"紫外可见光谱","originalKeyword":"紫外可见光谱"},{"id":"7662c117-7566-4173-b784-d5cf69060062","keyword":"光谱曲线相似度","originalKeyword":"光谱曲线相似度"},{"id":"ef90b8b5-c334-453a-8346-0f1341f1e34b","keyword":"催<span style=\"color:red\">陈</span>效果","originalKeyword":"催陈效果"}],"language":"zh","publisherId":"yzhwlpl201402017","title":"电子束辐照浓香型白酒催<span style=\"color:red\">陈</span>效果的研究","volume":"","year":"2014"},{"abstractinfo":"通过光片鉴定和电子探针分析,总结了内蒙古赤峰<span style=\"color:red\">陈</span>家杖子金矿床的矿石矿物组成,结构构造,划分了成矿期次.研究表明:矿床中矿石成分较复杂,硫化物种类多,有少量硫盐矿物出现;富硫贫砷毒砂、贫砷富硫黄铁矿、贫锌富铁的闪锌矿(与标准分子式相比),含杂质多的银锑黝铜矿和方铅矿与金关系密切;多金属硫化物阶段是该矿床的主要成矿阶段,其中第二世代富硫贫砷毒砂是<span style=\"color:red\">陈</span>家杖子金矿的最主要载金矿物,其次是方铅矿.结合流体包裹体测试和研究,确定该矿床为受大型角砾岩筒构造控制的低硫化型浅成低温热液矿床,该矿床深部有很大的找矿潜力.","authors":[{"authorName":"霍亮","id":"aa8459a3-b8df-471f-beb6-c0820f947fb7","originalAuthorName":"霍亮"},{"authorName":"李碧乐","id":"0542a65f-639d-436f-9395-33a31da28fa5","originalAuthorName":"李碧乐"},{"authorName":"黄勇","id":"c3eb9700-f7a0-4640-951f-31133483900c","originalAuthorName":"黄勇"},{"authorName":"王力","id":"74c22902-9e7c-40f8-8cad-6d663cf193da","originalAuthorName":"王力"}],"doi":"10.3969/j.issn.1001-1277.2007.10.002","fpage":"4","id":"d9d6227a-88ea-4727-89c6-a72289a7a8f9","issue":"10","journal":{"abbrevTitle":"HJ","coverImgSrc":"journal/img/cover/HJ.jpg","id":"44","issnPpub":"1001-1277","publisherId":"HJ","title":"黄金"},"keywords":[{"id":"342763a1-a09a-4924-a3cd-d93fd15d2580","keyword":"矿石矿物特征","originalKeyword":"矿石矿物特征"},{"id":"5ed5d2c9-7efa-4ac6-91b8-a288a651641c","keyword":"矿床成因","originalKeyword":"矿床成因"},{"id":"196f3b92-1f65-4e1d-a829-9ab98bb8b116","keyword":"<span style=\"color:red\">陈</span>家杖子金矿床","originalKeyword":"陈家杖子金矿床"}],"language":"zh","publisherId":"huangj200710002","title":"内蒙古赤峰<span style=\"color:red\">陈</span>家杖子金矿床矿物学特征及成因","volume":"28","year":"2007"},{"abstractinfo":"","authors":[],"doi":"","fpage":"46","id":"b10481d8-9fcb-4ee7-8505-4f79d8427c8a","issue":"4","journal":{"abbrevTitle":"JXGCCL","coverImgSrc":"journal/img/cover/JXGCCL.jpg","id":"45","issnPpub":"1000-3738","publisherId":"JXGCCL","title":"机械工程材料"},"keywords":[{"id":"710c4de7-f7cc-4461-8c11-e77989cb348b","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"jxgccl200104016","title":"沉痛悼念<span style=\"color:red\">陈</span>南平教授","volume":"25","year":"2001"},{"abstractinfo":"","authors":[{"authorName":"胡包钢","id":"8303dfbd-7cee-49e7-8a35-d4094812e08c","originalAuthorName":"胡包钢"}],"doi":"10.3969/j.issn.1000-6826.2013.01.022","fpage":"80","id":"581e3c9f-7d6a-4ed1-8fc2-71bd2e460d6d","issue":"1","journal":{"abbrevTitle":"JSSJ","coverImgSrc":"journal/img/cover/3abe017a-2574-4821-8152-4ae974ef0471.jpg","id":"47","issnPpub":"1000-6826","publisherId":"JSSJ","title":"金属世界"},"keywords":[{"id":"d8c3d45d-172d-4c0d-b45b-c643cc9a574c","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"jssj201301023","title":"师者风范——怀念恩师<span style=\"color:red\">陈</span>先霖先生","volume":"","year":"2013"},{"abstractinfo":"","authors":[],"doi":"","fpage":"347","id":"17627adf-fab0-4402-8bdd-938519458bcf","issue":"6","journal":{"abbrevTitle":"DDYTS","coverImgSrc":"journal/img/cover/DDYTS.jpg","id":"21","issnPpub":"1004-227X","publisherId":"DDYTS","title":"电镀与涂饰   "},"keywords":[{"id":"564cdbaf-f522-465d-8876-de6c91dea3cd","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"ddyts201506016","title":"《涂料及检测技术》（<span style=\"color:red\">陈</span>卫星、侯永刚、石玉编著）等","volume":"","year":"2015"},{"abstractinfo":"","authors":[],"doi":"","fpage":"804","id":"81e36271-543b-43e0-984b-21e1f450eeac","issue":"10","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报   "},"keywords":[{"id":"f93531ec-3a57-4ae7-ad8a-50258b3356d3","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"cuihuaxb200310019","title":"Journal of Catalysis编委<span style=\"color:red\">陈</span>懿教授给<催化学报>主编林励吾院士的来信","volume":"24","year":"2003"},{"abstractinfo":"","authors":[{"authorName":"丁维平","id":"0756e5f2-bbcb-4083-8bd1-85baea02dd0f","originalAuthorName":"丁维平"},{"authorName":"侯文华","id":"2c970de8-4f6a-4d6b-b9e0-9411ce858926","originalAuthorName":"侯文华"},{"authorName":"董林","id":"bb3060ed-c70c-41ca-b953-90a4426587fd","originalAuthorName":"董林"}],"doi":"10.1016/S1872-2067(12)60725-6","fpage":"1961","id":"bf85ba67-8735-413c-91f7-01dbd8ff4d02","issue":"11","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报   "},"keywords":[{"id":"92b740fe-6b7e-4953-9e37-43b57a4ec3d5","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"cuihuaxb201311001","title":"《催化学报》以本期专刊的出版庆祝<span style=\"color:red\">陈</span>懿先生八十华诞","volume":"34","year":"2013"},{"abstractinfo":"","authors":[],"doi":"","fpage":"354","id":"7383e1b0-3ed1-4def-8416-6d0851c6fb9b","issue":"6","journal":{"abbrevTitle":"DDYTS","coverImgSrc":"journal/img/cover/DDYTS.jpg","id":"21","issnPpub":"1004-227X","publisherId":"DDYTS","title":"电镀与涂饰   "},"keywords":[{"id":"d56430c5-665e-474a-bd95-22b7e0d8d52f","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"ddyts201506018","title":"《地坪涂料与涂装技术》（<span style=\"color:red\">陈</span>文广、梁剑锋、周子鹄等编著）等","volume":"","year":"2015"},{"abstractinfo":"","authors":[{"authorName":"解红叶","id":"10b789dd-0344-4b19-b427-2ce43c2f2b2b","originalAuthorName":"解红叶"}],"doi":"10.3969/j.issn.1000-6826.2012.05.024","fpage":"69","id":"a1d80e98-014b-412a-a8c0-6a7f135b8998","issue":"5","journal":{"abbrevTitle":"JSSJ","coverImgSrc":"journal/img/cover/3abe017a-2574-4821-8152-4ae974ef0471.jpg","id":"47","issnPpub":"1000-6826","publisherId":"JSSJ","title":"金属世界"},"keywords":[{"id":"4b3e8af4-ca78-497f-82f4-2290098ca06b","keyword":"","originalKeyword":""}],"language":"zh","publisherId":"jssj201205024","title":"板形之先,满井之霖——记冶金机械专家、中国工程院院士<span style=\"color:red\">陈</span>先霖","volume":"","year":"2012"}],"totalpage":3,"totalrecord":30}