为调控骨组织工程支架的力学性能和降解性能,采用相分离方法,以冰醋酸一水为共溶剂配制聚合物溶液,以NaOH溶液为凝固剂,以CS为添加剂制备壳聚糖(CS)/N己内酯(PCL)-聚乳酸(PLA)三维多孔支架,研究了聚合物质量比对支架结构、形貌、孔隙率、力学性能和降解性能的影响.实验结果表明,CS和基体存在相互作用,CS有利于形成三维相互贯通的微孔结构,但CS的存在会使基体中各组分的熔点降低.随着PCL和PLA用量比例的改变,孔径范围和微孔形貌发生了一系列的变化.当PCL∶PLA为2∶4和3∶3时,所制备的支架孔隙率均大于90%,当进一步增大PCL质量比时,孔隙率迅速下降.抗压测试表明,所制备的支架弹性模量为0.8～8.0 MPa.降解性能分析表明,4周以后,当PCL∶PLA为3∶3时,质量损失率最大,达到5.94%.该分析表明采用相分离法,通过调节PCL和PLA的质量比可制备形貌、孔隙率、降解速率和力学性能满足要求的三维多孔支架材料,有望应用在软骨组织工程上.
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