主要对多孔β-TCP生物陶瓷在体内对新骨生成的诱导性进行研究.首先,人为造成兔股骨髁部骨腔洞,建立骨缺损模型,将自制β-TCP多孔陶瓷植入,然后逐月取一系列处死、取材,并综合运用扫描电镜观察(SEM)、电子探针X显微分析(EPMA)、甲苯胺蓝染色(toluidine blue staining,TBS)和四环素双标记法(tetracycline double labeling,TDL)等测试手段,对材料植入区进行研究,试图探明β-TCP多孔陶瓷修复骨缺损时的成骨过程.
参考文献
| [1] | Hubert S F.Ceramics in clinical applications past,present and future[A].,1986:189. |
| [2] | LeGeros R Z .Biodergradation and bioresorption of calcium ceramics[J].Clinical Materials,1993,14:65-88. |
| [3] | Delloye C.Considerations actuelles sur les greffes[A].France: Biomat Edn, Bordeaux,1987:149-163. |
| [4] | 阎玉华;许原;戴红莲 等.可降解β-Ca3(PO4)2陶瓷的物化性能与生物性能[J].武汉工业大学学报,1995,17(04):116-127. |
| [5] | Zyman Z;Ivanov I;Glushko V;Dedukh N;Malyshkina S .Inorganic phase composition of remineralisation in porous CaP ceramics.[J].Biomaterials,1998(14):1269-1273. |
| [6] | Paul Ducheyne;Radin S;King L .The effect of calcium phosphate ceramic composition and structure on In Vitro behavior. I. Dissolution[J].Journal of Biomedical Materials Research,1993,27:25-34. |
| [7] | 陈芳;李世普;江昕 等.发泡法制备TCP陶瓷的工艺几其结构与性能研究[J].中国生物医学工程学报,1999,18(03):260-271. |
| [8] | 陈晓明,张士诚,刘秋霞.β-Ca3（PO4）2陶瓷人工骨的组成与结构特征[J].武汉工业大学学报,1995(04):136-139. |
| [9] | Parffit A M;Drezner M K;Glorieux FH et al.Bone histomorphometry standardization of nomenclature,symbols and units[J].Journal of Bone and Mineral Research,1987,2:595-610. |
| [10] | Yamada S;Nakamura T;Kokubo T et al.Degradation of the apatie layer formed on bioactive ceramics and the undertying ceramic surface by ostoclasts in a culture system[J].Cells and Materials,1994,4:347-356. |
| [11] | Jarcho M.Calcium phosphate ceramics as haed tissue prosthetics[J].Clinical Orthopaedics & Related Research,1981:157-259. |
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