HA/聚合物生物降解复合材料在一定程度上模仿了天然骨,可降解聚合物成分逐渐被机体溶解吸收或新陈代谢排出,HA陶瓷成分在体液的作用下,会发生部分降解,游离出钙和磷,并被人体组织吸收、利用、生长出新的组织;同时可降解聚合物成分对HA的过快降解具有控制作用,使得HA降解与新生骨组织生成速率匹配.总结了羟基磷灰石/聚合物可降解生物复合材料的最新研究进展,并分析了目前该材料在研究和临床应用上存在的问题,讨论了其未来的发展方向.
参考文献
[1] | 俞耀庭;张兴栋.生物医用材料[M].天津:天津大学出版社,2000:13. |
[2] | 李世普.生物医用材料导论[M].武昌:武汉工业大学出版社,2000:84. |
[3] | Toshiaki Kitsugi;Takao Yamamuro;Takashi Nakamura et al.Four calcium phosphate ceramics as bone substitutes for non-weight-bearing[J].Biomaterials,1993,14:216. |
[4] | Ducheyne P;Qiu Q .Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function.[J].Biomaterials,1999(23/24):2287-2303. |
[5] | Makarand G Joshi;Suresh G Advani;Freeman Miller et al.Analysis of a femoral hip prosthesis designed to reduce stress shielding[J].Journal of Biomechanics,2000,33:1655. |
[6] | Shin Hasegawa;Shinsuke Ishii;Jiro Tamura.A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide)composite rods for the internal fixation of bone fractures[J].BIOMATERIALS,2005 |
[7] | Rodrigues CVM.;Serricella P.;Linhares ABR.;Guerdes RM.;Borojevic R. Rossi MA.;Duarte MEL.;Farina M. .Characterization of a bovine collagen-hydroxyapatite composite scaffold for bone tissue engineering[J].Biomaterials,2003(27):4987-4997. |
[8] | Hae-Wan Kin;Hyoun-Ee Kim;Vehid Salih .Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds[J].Biomaterials,2005,26:5221. |
[9] | 牛丽婷,刘敬肖,周靖,王继红.聚乙烯醇改性羟基磷灰石超细粉的制备及表征[J].大连轻工业学院学报,2004(04):239-241. |
[10] | Hong Zhongkui;Zhang Peibiao;He Chaoliang et al.Nano-composite of poly(L-lactide)and surface grafted hydroxyapatite:Mechanical properties and biocompatibility[J].Biomaterials,2005,26:6296. |
[11] | 林晓艳,温贤涛,李虎,鲁建,范红松,张兴栋.共滴定法制备纳米羟基磷灰石/胶原复合材料及其性能[J].四川大学学报(工程科学版),2004(04):67-70. |
[12] | Nenad Ignjatovic;Dragan Uskokovic .Synthesis and application of hydroxyapatite/polylactide composite biomaterial[J].Applied Surface Science,2004,238:314. |
[13] | 张利,李玉宝,魏杰,左奕,韩纪梅,吴兰,王学江.纳米羟基磷灰石/壳聚糖复合骨修复材料的共沉淀法制备及其性能表征[J].功能材料,2005(03):441-444. |
[14] | 李亚军,阮建明.聚乳酸/羟基磷灰石复合型多孔状可降解生物材料[J].中南工业大学学报(自然科学版),2002(03):261-265. |
[15] | Verheyen C C P M .Restorable materials with bone bonding ability,evaluation of hydroxyapatite/poly(L-lactide)composites[D].Leiden:University of Leiden,1993. |
[16] | Zhang S M;Liu J;Zhou W et al.Interfacial fabrication and property of hydroxyapatite/polylactide resorbable bone fixation composites[J].Current Applied Physics,2005,5:516. |
[17] | 全大萍,李世普,袁润章.聚DL-丙交酯/羟基磷灰石(PDLLA/HA)复合材料--Ⅱ:硅烷偶联剂处理羟基磷灰石表面的作用研究[J].复合材料学报,2000(04):114. |
[18] | Chen Biqiong;Sun Kang .Poly(ε-caprolactone)/Hydroxy-apatite composites:effects of particle size,molecular weight distribution and irradiation on interfacial interaction and properties[J].Polymer Testing,2005,24:64. |
[19] | Hong Zhongkui;Zhang Peibiao;He Chaoliang et al.Nano-composite of poly(L-lactide)and surface grafted hydroxyapatite:Mechanical properties and biocompatibility[J].Biomaterials,2005,26:6296. |
[20] | Wei Jie;Li Yubao .Tissue engineering scaffold material of nano-apatite crystals and polyamide composite[J].European Polymer Journal,2004,40:509. |
[21] | 王迎军,刘青,郑裕东,吴刚.沉淀法原位复合聚乙烯醇(PVA)/羟基磷灰石(HA)水凝胶的结构与性能研究[J].中国生物医学工程学报,2005(02):150-153. |
[22] | 孙恩杰,杨冬,颜文龙.羟基磷灰石-明胶复合物的制备及表征[J].化学与生物工程,2005(06):49-51. |
[23] | Roveri N;Falini G;Sidoti M C et al.Biologically inspired growth of hydroxyapatite nanocrystals inside self-assembled collagen fibers[J].Materials Science and Engineering,2003,23:441. |
[24] | Masanori Kikuchi;Toshiyuki Ikoma;Soichiro Itoh .Biomimetic synthesis of bone-like nanocomposites using the self-organization mechanism of hydroxyapatite and collagen[J].Composites science and technology,2004(6):819-825. |
[25] | 王振林,闫玉华,万涛.羟基磷灰石/胶原类骨仿生复合材料的制备及表征[J].复合材料学报,2005(02):83-86. |
[26] | Myung Chul Chang;Ching-Chang Ko;William H Douglas .Preparation of hydroxyapatite-gelatin nanocomposite[J].BIOMATERIALS,2003,24:2853. |
[27] | 张利,李玉宝,杨爱萍,左奕,吕国玉,魏杰.骨组织工程用纳米羟基磷灰石/ 壳聚糖多孔支架材料的制备及性能表征[J].功能材料,2005(02):314-317. |
[28] | Jansen JA.;Janssen PTM.;Paquay YGGJ.;Deruijter JE. .HISTOLOGICAL EVALUATION OF A BIODEGRADABLE POLYACTIVE(R)/HYDROXYAPATITE MEMBRANE[J].Biomaterials,1995(11):819-827. |
[29] | 赵忠华,薛平,何亚东,朱复华.用TIPS法成型超高分子量聚乙烯微孔材料的机理分析[J].高分子材料科学与工程,2003(01):24-27,31. |
[30] | 程俊秋,段可,翁杰,张兴栋.多孔纳米羟基磷灰石-聚乳酸复合材料的[J].化学研究与应用,2001(05):517-520. |
[31] | Hu Q;Li B;Wang M;Shen J .Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture.[J].Biomaterials,2004(5):779-785. |
[32] | Boix T;Gomez-Morales J;Torrent-Burgues J;Monfort A;Pulgdomenech P;Rodriguez-Clemente R .Adsorption of recombinant human bone morphogenetic protein rhBMP-2m onto hydroxyapatite[J].Journal of Inorganic Biochemistry: An Interdisciplinary Journal,2005(5):1043-1050. |
[33] | 江涛,胡平.聚β-羟基丁酸酯/羟基磷灰石复合材料的制备与性能[J].高分子材料科学与工程,2002(04):45-48. |
[34] | 董福慧.骨生物力学回顾[J].中国骨伤,2000(06):323. |
[35] | 王远亮,蔡绍皙.生物力学与骨组织工程[J].力学进展,1999(02):232. |
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