Study on β-TCP Coated Porous Mg as a Bone Tissue Engineering Scaffold Material

材料科学技术（英）, 2009, 25(1): 123-129.

^1, , ^2, , ^3, , ^4, , ^5, , ^6, , ^7,

1.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;Graduate School of Chinese Academy of Sciences, Beijing 100049, China

2.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

3.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

4.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

5.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

6.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

7.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

基金项目: 中国科学院资助项目(KGCX2-YW-207)

Study on β-TCP Coated Porous Mg as a Bone Tissue Engineering Scaffold Material

Fang Geng ^1, , Lili Tan ^2, , Bingchun Zhang ^3, , Chunfu Wu ^4, , Yonglian He ^5, , Jingyu Yang ^6, , Ke Yang ^7,

1.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;Graduate School of Chinese Academy of Sciences, Beijing 100049, China

2.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

3.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

4.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

5.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

6.Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

7.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

Keywords： Magnesium

Three-dimensional honeycomb-structured magnesium (Mg) scaffolds with interconnected pores of accurately controlled pore size and porosity were fabricated by laser perforation technique. Biodegradable and bioactive β-tricalcium phosphate (β-TCP) coatings were prepared on the porous Mg to further improve its biocompatibility, and the biodegradation mechanism was simply evaluated in vitro. It was found that the mechanical properties of this type of porous Mg significantly depended on its porosity. Elastic modulus and compressive strength similar to human bones could be obtained for the porous Mg with porosity of 42.6%-51%. It was observed that the human osteosarcoma cells (UMR106) were well adhered and proliferated on the surface of the β-TCP coated porous Mg, which indicates that the β-TCP coated porous Mg is promising to be a bone tissue engineering scaffold material.

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Study on β-TCP Coated Porous Mg as a Bone Tissue Engineering Scaffold Material

参考文献