Neurochip Based on Light-addressable Potentiometric Sensor

稀有金属材料与工程, 2006, 35(z2): 413-416.

Qingjun Liu ^1, , Hua Cai ^2, , Ying Xu ^3, , Lifeng Qin ^4, , Lijiang Wang ^5, , Ping Wang ^6,

1.Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China;State Key Laboratory of Transducer Technology, Chinese Academy of Scien

2.Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

3.Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China;State Key Laboratory of Transducer Technology, Chinese Academy of Scien

4.Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

5.Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

6.Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China;State Key Laboratory of Transducer Technology, Chinese Academy of Scien

基金项目: the Project of State Key Laboratory of Transducer Technology of China(Grant SKT0403) the Foundation for the Bureau of Zhejiang Province o the National Natural Science Foundation of China(Grant . 30270387, 30570492)

Neurochip Based on Light-addressable Potentiometric Sensor

Keywords： neurochip

A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed. Using its light addressable characteristic. The problems of the limitations of restricted discrete active sites of current neurochips, such as microelectrode array and field effect transistor array can be settled easily. Based on the theoretical analysis of the interface between cells and LAPS, spontaneously discharges of hippocampal neurons induced by Mg2+-free media treatment were recorded by LAPS. The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.

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Neurochip Based on Light-addressable Potentiometric Sensor

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