电纺丝技术是利用高压静电将聚合物或具有粘弹性的溶液制备成纳米级直径纤维的一种加工技术。电纺丝纤维膜由于其高比表面积、良好的生物仿生性能,在生物组织工程支架、药物载释、伤口修复等方面有较高的应用价值。近年来,大量文献报道,通过对电纺丝装置以及纺丝过程参数的改进和优化,制备出功能化和具有特殊结构的纳米纤维材料。本文从电纺丝装置的改进、纺丝过程优化等方面简述了电纺丝技术的进展。概述了电纺丝法制备特殊结构的纳米纤维的方法,及其在生物组织工程、药物载释等方面的应用。
Electrospinning is a promising technology to prepare nanofibers from polymer solutions or viscoelastic solutions based on high voltage electrostatic repulsions.Electrospun nanofiber mats have been extensively studied and applied in tissue engineering,drug delivery and wound dressing,due to their amazing properties,such as high surface area to volume ratio,high porosity and excellent biological property.Recently,nanofibers with various functionalities and special nanostructures have been prepared via electrospinning by improving electrospinning devices and optimizing process parameters.This article presents a brief overview on the progress of electrospinning process,optimizing and improvement of electrospinning devices.The approaches to prepare special structure nanofibers were summarized.The recent applications of elecrospun nanofiber mats in biomedical fields such as tissue engineering,drug delivery,wound dressing were also illustrated.
参考文献
| [1] | Formhals A .Process and apparatus for preparing artificial threads[P].US Patent 1975504,1934-10-02. |
| [2] | Tack Gyoung Kim;Hyun Jung Chung et al.Macroporous and nanofibers hyaluronic acid/collagen hybrid scaffold fabricated by concurrent electrospinning and deposition/leaching of salt particles[J].Acta biomaterials,2008,4:1611-1619. |
| [3] | Lee KY;Jeong L;Kang YO .Electrospinning of polysaccharides for regenerative medicine.[J].Advanced drug delivery reviews,2009(12):1020-1032. |
| [4] | Z.-M. Huang;C.-L. He;A.Yang .Encapsulating Drugs in Biodegradable Ultrafine Fibers Through Co-Axial Electrospinning[J].Journal of biomedical materials research, Part A,2006(1):169-179. |
| [5] | Kyong So Rho;Lim Jeong;Gene Lee et al.Electrospinning of collagen nanofibers:Effects on behavior of normal human keratinocytes and early wound healing[J].Biomaterials,2006,27:1452-1461. |
| [6] | Dongzhi Yang;Yanning Li;Jun Nie .Preparation of gelatin/PVA nanofibers and their potential application in controlled release of drugs[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2007(3):538-543. |
| [7] | Yangliu,Guiping;Ma, Dawei Fang;Hongwen Zhang;Jun Nie .Effects of solution properties and eleetric field on the electrospinning of hyaluronie aeid[J].Carbohydrate Polymers,2011,83(02):1011-1015. |
| [8] | Dan Li;Jesse T. McCann;Younan Xia .Use of Electrospinning to Directly Fabricate Hollow Nanofibers with Functionalized inner and Outer Surfaces[J].Small,2005(1):83-86. |
| [9] | Li D;McCann JT;Xia YN .Electrospinning: A simple and versatile technique for producing ceramic nanofibers and nanotubes[J].Journal of the American Ceramic Society,2006(6):1861-1869. |
| [10] | Dan Li;Yuliang Wang;Younan Xia .Electrospinning of Polymeric and Ceramic Nanofibers as Uniaxially Aligned Arrays[J].Nano letters,2003(8):1167-1171. |
| [11] | Shui, JL;Li, JCM .Platinum Nanowires Produced by Electrospinning[J].Nano letters,2009(4):1307-1314. |
| [12] | R. S. Barhate Seeram Ramakrishna .Nanofiber filteririg media: filtration problems and solutions from tiny materials[J].Journal of Membrane Science,2007,296:1-8. |
| [13] | Eric Formo;Eric Lee;Dean Campbell;Younan Xia .Functionalization of eleetrospun TiO2 nanofibers with Ptnanoparticels and nanowires for catalytic applications[J].Nano Letters,2008,8:668-672. |
| [14] | Zhang, Jian-Feng;Yang, Dong-Zhi;Xu, Fei;Zhang, Zi-Ping;Yin, Rui-Xue;Nie, Jun .Electrospun Core-Shell Structure Nanofibers from Homogeneous Solution of Poly(ethylene oxide)/Chitosan[J].Macromolecules,2009(14):5278-5284. |
| [15] | J.M.Deitzel;J.D.Kleinmeyer;J.K.Hirvonen;N.C.Beck Tan .Controlled deposition of electrospun poly(ethylene oxide) fibers[J].Polymer: The International Journal for the Science and Technology of Polymers,2001(19):8163-8170. |
| [16] | Ignacio G. Loscertales;Antonio Barrero;Manuel Marquez;Ruben Spretz;Raffet Velarde-Ortiz;Gustavo Larsen .Electrically Forced Coaxial Nanojets for One-Step Hollow Nanofiber Design[J].Journal of the American Chemical Society,2004(17):5376-5377. |
| [17] | Dan Li;Younan Xia .Direct Fabrication of Composite and Ceramic Hollow Nanofibers by Electrospinning[J].Nano letters,2004(5):933-938. |
| [18] | YiXin;Zonghao Huang;Wenwen Li et al.Core-sheath functional polymer nanofibers prepared by ec-eleetrospinning[J].European Polymer Journal,2008,44:1040-1045. |
| [19] | Chen, H.;Wang, N.;Di, J.;Zhao, Y.;Song, Y.;Jiang, L. .Nanowire-in-microtube structured core/shell fibers via multifluidic coaxial electrospinning[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(13):11291-11296. |
| [20] | S.A. Theron;A. L. Yarin;E. Zussman;E.Kroll .Multiple iets in eleetrospinning; experiment and modeling[J].Polymer,2005,46:2889-2899. |
| [21] | Kim G;Cho YS;Kim WD .Stability analysis for multi jets electrospinning process modified with a cylindrical electrode[J].European Polymer Journal,2006(9):2031-2038. |
| [22] | Jesse T.McCann;Manuel Marquez;Younan Xia .Highly Porous Fibers by Electrospinning into a Cryogenic Liquid[J].Journal of the American Chemical Society,2006(5):1436-1437. |
| [23] | Huarong Nie;Aihua He;Jianfen Zheng .Effects of Chain Conformation and Entanglement on the Electrospinning of Pure Alginate[J].Biomacromolecules,2008(5):1362-1365. |
| [24] | Katta P;Alessandro M;Ramsier RD;Chase GG .Continuous electrospinning of aligned polymer nanofibers onto a wire drum collector[J].Nano letters,2004(11):2215-2218. |
| [25] | Xu CY;Inai R;Kotaki M;Ramakrishna S .Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering.[J].Biomaterials,2004(5):877-886. |
| [26] | Dan Li;Yuliang Wang;Younan Xia .Electrospinning Nanofibers as Uniaxially Aligned Arrays and Layer-by-Layer Stacked Films[J].Advanced Materials,2004(4):361-366. |
| [27] | Yang DZ;Zhang JF;Zhang J;Nie J .Aligned Electrospun Nanofibers induced by Magnetic Field[J].Journal of Applied Polymer Science,2008(6):3368-3372. |
| [28] | Dayong Yang;Bo Lu;Yong Zhao;Xingyu Jiang .Fabrication of Aligned Fibrous Arrays by Magnetic Electrospinning[J].Advanced Materials,2007(21):3702-3706. |
| [29] | Yaqing Liu;Xinping Zhang;Younan Xia;Hong Yang .Magnetic-Field-Assisted Electrospinning of Aligned Straight and Wavy Polymeric Nanofibers[J].Advanced Materials,2010(22):2454-457,2390. |
| [30] | A. L. Yarin;S. Koombhongse;D. H. Reneker .Taylor cone and jetting from liquid droplets in electrospinning of nanofibers[J].Journal of Applied Physics,2001(9):4836-4846. |
| [31] | Darrell H.Reneker;Alexander L.Yarin .Electrospinning jets and polymer nanofibers[J].Polymer: The International Journal for the Science and Technology of Polymers,2008(10):2387-2425. |
| [32] | D.H. Reneker;Y. L. Yarin;E. Zussman;H.Xu .Electrospinning nanofibers from polyemr solutions and melts[J].Advances in Applied Mechanics,2007,41:t43-184. |
| [33] | Y. M. Shin;M. M. Hohman;M. P. Brenner .Experimental characterization of electrospinning: the electrically forced jet and instabilities[J].Polymer: The International Journal for the Science and Technology of Polymers,2001(25):9955-9967. |
| [34] | J.J. Feng .Stretching of a straight electrically charged viscoelastic jet[J].Journal of Non-Newtonian Fluid Mechanics,2003,116:55-70. |
| [35] | K.H.Lee;H.Y.Kim;H.J.Bang;Y.H.Jung;S.G.Lee .The change of bead morphology formed on electrospun polystyrene fibers[J].Polymer: The International Journal for the Science and Technology of Polymers,2003(14):4029-4034. |
| [36] | H. Fong;I. Chun;D.H. Reneker .Beaded nanofibers formed during electrospinning[J].Polymer: The International Journal for the Science and Technology of Polymers,1999(16):4585-4592. |
| [37] | Shenoy SL;Bates WD;Frisch HL;Wnek GE .Role of chain entanglements on fiber formation during electrospinning of polymer solutions: good solvent, non-specific polymer-polymer interaction limit[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(10):3372-3384. |
| [38] | S-H.Tan;R.Inai;M.Kotaki;S.Ramakrishna .Systematic parameter study for ultra-fine fiber fabrication via electrospinning process[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(16):6128-6134. |
| [39] | Pakakrong Sangsanoh;Pitt Supaphol .Stability Improvement of Electrospun Chitosan Nanofibrous Membranes in Neutral or Weak Basic Aqueous Solutions[J].Biomacromolecules,2006(10):2710-2714. |
| [40] | Yang Liu;Guiping Ma;Dawei Fang .Effects of solution properties and electric field on the electrospinning of hyaluronic acid[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(2):1011-1015. |
| [41] | Jian-Wei Lu;Yong-Liang Zhu;Zhao-Xia Guo .Electrospinning of sodium alginate with poly(ethylene oxide)[J].Polymer: The International Journal for the Science and Technology of Polymers,2006(23):8026-8031. |
| [42] | Muhammad Miftahul Munir;Adi Bagus Suryamas;Ferry Iskandar;Kikuo Okuyama .Scaling law on particle-to-fiber formation during electrospinning[J].Polymer: The International Journal for the Science and Technology of Polymers,2009(20):4935-4943. |
| [43] | Dawei Fang;Yang Liu;Shan Jiang .Effect of intermolecular interaction on electrospinning of sodium alginate[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(1):276-279. |
| [44] | Bumsu Kim;Hyun Park;Sung-Hwan Lee .Poly(acrylic acid) nanofibers by electrospinning[J].Materials Letters,2005(7):829-832. |
| [45] | Dan Li;Younan Xia .Electrospinning of Nanofibers: Reinventing the Wheel?[J].Advanced Materials,2004(14):1151-1170. |
| [46] | Uyar T;Besenbacher F .Electrospinning of uniform polystyrene fibers: The effect of solvent conductivity[J].Polymer: The International Journal for the Science and Technology of Polymers,2008(24):5336-5343. |
| [47] | CJ.Thompson;G.G.Chase;A.L.Yarin .Effects of parameters on nanofiber diameter determined from electrospinning model[J].Polymer: The International Journal for the Science and Technology of Polymers,2007(23):6913-6922. |
| [48] | Huarong Nie;Aihua He;Wanling Wu;Jianfen Zheng;Shanshan Xu;Junxing Li;Charles C. Han .Effect of poly(ethylene oxide) with different molecular weights on theelectrospinnability of sodium alginate[J].Polymer: The International Journal for the Science and Technology of Polymers,2009(20):4926-4934. |
| [49] | F.Weinbreck;R.H.Tromp;C.G.DeKruif .Electro-Spinning and Electro-Blowing of Hyaluronic Acid[J].Biomacromolecules,2004(4):1428-1436. |
| [50] | Mao Peng;Dasong Li;Lie Shen et al.Nanoporous Structured Submicrometer Carbon Fibers Prepared via Solution Electrospinning of Polymer Blend[J].Langmuir,2006,22:9368-9374. |
| [51] | Dan Li;Younan Xia .Fabrication of Titania Nanofibers by Eleetrospinning[J].Nano Letters,2003,3:555-560. |
| [52] | Zhonghua Qi;Hao Yu;Yanmo Chen;Meifang Zhu .Highly Porous Fibers Prepared By Electrospinning A Ternary System Of Nonsolvent/solvent/poly(l-lactic Acid)[J].Materials Letters,2009(3/4):415-418. |
| [53] | Cheryl L.Casper;Jean S.Stephens;Nancy G.Tassi;D.Bruce Chase;John F.Rabolt .Controlling Surface Morphology of Electrospun Polystyrene Fibers:Effect of Humidity and Molecular Weight in the Electrospinning Process[J].Macromolecules,2004(2):573-578. |
| [54] | M. Bognitzki;W. Czado et al.Nanostructured fibers xia Eleetr0spinning[J].Advanced Materials,2001,13:70-72. |
| [55] | Muthiah, P.;Hsu, S.-H.;Sigmund, W. .Coaxially electrospun PVDF-teflon AF and teflon AF-PVDF core-sheath nanofiber mats with superhydrophobic properties[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(15):12483-12487. |
| [56] | Mao Wang;Jian H.Yu;David L.Kaplan;Gregory C.Rutledge .Production of Submicron Diameter Silk Fibers under Benign Processing Conditions by Two-Fluid Electrospinning[J].Macromolecules,2006(3):1102-1107. |
| [57] | Minglin Ma;Vahik Krikorian;Jian H. Yu et al.Rutledg. Eleetrospun Polymer Nanofibers with Internal Periodic Structure Obtained by Microphase Separation of Cylindrically Confined Block Copolymers[J].Nano Letters,2006,6:2969-2972. |
| [58] | Bazilevsky AV;Yarin AL;Megaridis CM .Co-electrospinning of core-shell fibers using a single-nozzle technique[J].Langmuir: The ACS Journal of Surfaces and Colloids,2007(5):2311-2314. |
| [59] | Ming Wei;Bongwoo Kang;Changmo Sung .Core-Sheath Structure in Electrospun Nanofibers from Polymer Blends[J].Macromolecular materials and engineering,2006(11):1307-1314. |
| [60] | HaoqingHou;Zeng Jun;Arndt Reuning et al.[J].Macromolecules,2002,35:2429-2431. |
| [61] | G. D. Fu;J. Y. Lei;C. Yao;X.S.Li,F.Yao .Core-Sheath Nanofibers from Combined Atom Transfer Radical Polymerization and Eleetrospinning[J].Maeromoleeules,2008,41:6854-6858. |
| [62] | Martin Graeser;Eckhard Pippel;Andreas Greiner .Polymer Core-Shell Fibers with Metal Nanoparticles as Nanoreactor for Catalysis[J].Macromolecules,2007(17):6032-6039. |
| [63] | Chan Kim;Young Il Jeong;Bui Thi Nhu Ngoc;Kap Seung Yang;Masahito Kojima;Yoong Ahm Kim;Morinobu Endo;Jae-Wook Lee .Synthesis and Characterization of Porous Carbon Nanofibers with Hollow Cores Through the Thermal Treatment of Electrospun Copolymeric Nanofiber Webs[J].Small,2007(1):91-95. |
| [64] | Yong Zhao;Xinyu Cao;and Lei Jiang .Bio-mimic Multichannel Microtubes by a Facile Method[J].Journal of the American Chemical Society,2007(4):764-765. |
| [65] | Bo-Yi Yu;Po-Ya Chen;Yi-Ming Sun .The behaviors of human mesenchymal stem cells on the poly(3 -hy droxybutyrate-co-3 -hydroxyhexanoate) (PHBHHx) membranes[J].Desalination: The International Journal on the Science and Technology of Desalting and Water Purification,2008(1/3):204-211. |
| [66] | Yoshimoto H;Shin YM;Terai H;Vacanti JP .A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering.[J].Biomaterials,2003(12):2077-2082. |
| [67] | Jeong SI;Kim SY;Cho SK;Chong MS;Kim KS;Kim H;Lee SB;Lee YM .Tissue-engineered vascular grafts composed of marine collagen and PLGA fibers using pulsatile perfusion bioreactors.[J].Biomaterials,2007(6):1115-1122. |
| [68] | Hyoung-Joon Jin;Sergey V. Fridrikh;et al. .[J].Biomacromolecules,2002,3:1233-1239. |
| [69] | Shaoping Zhong;Wee Eong Teo;Xiao Zhu;Roger Beuerman;Seeram Ramakrishna;Lin Yue Lanry Yung .Formation of Collagen-Glycosaminoglycan Blended Nanofibrous Scaffolds and Their Biological Properties[J].Biomacromolecules,2005(6):2998-3004. |
| [70] | Ko Eun Park;Hyun Ki Kang;Seung Jin Lee;Byung-Moo Min;Won Ho Park .Biomimetic Nanofibrous Scaffolds:Preparation and Characterization of PGA/Chitin Blend Nanofibers[J].Biomacromolecules,2006(2):635-643. |
| [71] | Junxing Li;Aihua He;Jianfen Zheng .Gelatin and Gelatin-Hyaluronic Acid Nanofibrous Membranes Produced by Electrospinning of Their Aqueous Solutions[J].Biomacromolecules,2006(7):2243-2247. |
| [72] | Keyur Desai;Kevin Kit;Jiajie Li .Morphological and Surface Properties of Electrospun Chitosan Nanofibers[J].Biomacromolecules,2008(3):1000-1006. |
| [73] | Sung In Jeong;Melissa D. Krebs;Christopher A. Bonino et al.Electrospun chitosan-alginate nanofibers with in situ polyelectrolyte eomplexation for use as tissue engineering seaffolds[J].Tissue Engineering,2011,17:59-70. |
| [74] | Chua KN;Lim WS;Zhang P;Lu H;Wen J;Ramakrishna S;Leong KW;Mao HQ .Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold.[J].Biomaterials,2005(15):2537-2547. |
| [75] | Y.Z.Zhang;J.Venugopal;Z.-M.Huang;C.T.Lim;S.Ramakrishna .Characterization of the Surface Biocompatibility of the Electrospun PCL-Collagen Nanofibers Using Fibroblasts[J].Biomacromolecules,2005(5):2583-2589. |
| [76] | Xiaoran Li;Jingwei Xie et al.Coating Electrospun Poly (ecaprolactone) Fibers with Gelatin and Calcium Phosphate and Their Use as Biomimetic Scaffolds for Bone Tissue Engineering[J].Langmuir,2008,24:14145-14150. |
| [77] | Eva Schnell;Kristina Klinkhammer;Simone Balzer et al.Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-e-caprolactone and a collagen/ poly-ε- caprolactone blend[J].Biomaterials,2007,28:3012-3025. |
| [78] | El-Refaie Kenawy;Fouad I. Abdel-Hay et al.Processing of polymer nanofibers through electrospinning as drug delivery systems[J].Materials Chemistry and Physics,2009,113:296302. |
| [79] | Maedeh Zamani;Mohammad Morshed;Jaleh Varshosaz;Marziyeh Jannesari .Controlled release of metronidazole benzoate from poly ε-caprolactone eleetrospun nanofibers for periodontal diseases[J].European Journal of Pharmaeeuties and Biopharmaceutics,2010,75:179-185. |
| [80] | Jing Zeng;Xiaoyi Xu;Xuesi Chen et al.[J].Journal of Controlled Release,2003,92:227-231. |
| [81] | Okuda, T;Tominaga, K;Kidoaki, S .Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2010(2):258-264. |
| [82] | Maretschek S;Greiner A;Kissel T .Electrospun biodegradable nanofiber nonwovens for controlled release of proteins[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2008(2):180-187. |
| [83] | Loh, XJ;Peh, P;Liao, S;Sng, C;Li, J .Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2010(2):175-182. |
| [84] | HongliangJiang;Yingqian Hu;Yan Li et al.A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioaciive agents[J].Journal of Controlled Release,2005,108:237-243. |
| [85] | Jon Zeng;Achim Aigner;Frank Czubayko et al.Wendorff, Andreas Greiner. Poly ( vinyl alcohol ) Nanofibers by Electrospinning as a Protein Delivery System and the Retardation of Enzyme Release by Additional Polymer Coatings [J][J].Biomacromolecules,2005,6:1484-1488. |
| [86] | Ye Yang;Xiaohong Li;Mingbo Qi;Shaobing Zhou Jie Weng .Release pattern and structural integrity of lysozyme encapsulated in core-sheath structured poly (DL-laetide) ultrafine fibers prepared by emulsion eleetrospinning[J].European Journal of Pharmaeeuties and Biopharmaceutics,2008,69:106-116. |
| [87] | Kyong Su Rho;Lira Jeong;Gene Lee et al.Electrospinning of eollagen nanofibersz Effects on the behavior of normal human keratinocytes and early-stage wound healing[J].Biomaterials,2006,27:1452-1461. |
| [88] | Hong KH .Preparation and properties of electrospun poly (vinyl alcohol)/silver fiber web as wound dressings[J].Polymer engineering and science,2007(1):43-49. |
| [89] | Abdulkareem Melaiye;Zhaohui Sun;Khadijah Hindi;Amy Milsted;Daniel Ely;Darrell H.Reneker;Claire A.Tessier;Wiley J.Youngs .Silver(I)-lmidazole Cyclophane gem-Diol Complexes Encapsulated by Electrospun Tecophilic Nanofibers:Formation of Nanosilver Particles and Antimicrobial Activity[J].Journal of the American Chemical Society,2005(7):2285-2291. |
| [90] | McCann JT;Lim BK;Ostermann R;Rycenga M;Marquez M;Xia YN .Carbon nanotubes by electrospinning with a polyelectrolyte and vapor deposition polymerization[J].Nano letters,2007(8):2470-2474. |
| [91] | Jingwei Xie;Matthew R. MacEwan;Stephanie M. Willerth;Xiaoran Li;Daniel W. Moran;Shelly E. Sakiyama-Elbert;Younan Xia .Conductive Core-Sheath Nanofibers and Their Potential Application in Neural Tissue Engineering[J].Advanced functional materials,2009(14):2297-2302. |
| [92] | Caruso RA.;Greiner A.;Schattka JH. .Titanium dioxide tubes from sol-gel coating of electrospun polymer fibers[J].Advanced Materials,2001(20):1577-0. |
| [93] | M. Bognitzki;H. Hou;M. Ishaque et al.[J].Advanced Materials,2000,12:637-640. |
| [94] | Shizhen Zhao;Bin Guo;Gaoyi Han;Yanni Tian .Metallization of electrospun polyacrylonitrile fibers by gold[J].Materials Letters,2008(21/22):3751-3753. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%