抗肿瘤骨水泥可以在骨修复的同时辅助治疗肿瘤,防止肿瘤复发与转移.目前抗肿瘤骨水泥的研究主要集中在可磁热疗抗肿瘤的磁性骨水泥、可缓释化疗药物抗肿瘤的载药骨水泥和可进行局部放疗抗肿瘤的放射性骨水泥.综述了这些抗肿瘤骨水泥的制备工艺及性能研究进展,并展望了抗肿瘤骨水泥的发展趋势.
参考文献
| [1] | Janeway KA;Walkley CR .Modeling human osteosarcoma in the mouse: From bedside to bench.[J].Bone,2010(5):859-865. |
| [2] | Vaiyapuri P S;Lee J .Metastatic tumours of bone[J].Surgery (Oxford),2012,30(02):80. |
| [3] | Buijs JT;van-der-Pluijm G .Osteotropic cancers: from primary tumor to bone.[J].Cancer letters,2009(2):177-193. |
| [4] | Lung F T;Kwok C W;Shekhar M K et al.Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone:A case control study[J].Bone,2008,42(01):68. |
| [5] | Noah F;Nicholas B;Fritz C E et al.The multidisciplinary management of osteosarcoma[J].Curr Treat Option Oncol,2009,10(1-2):82. |
| [6] | 刘昌胜.磷酸钙骨水泥的制备及其应用研究[J].材料导报,2001(02):38. |
| [7] | Jordan A.;Maier-Hauff K.;Johannsen M.;Wust P.;Nadobny J. Schirra H.;Schmidt H.;Deger S.;Loening S.;Lanksch W.;Felix R.;Scholz R. .Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia[J].Journal of Magnetism and Magnetic Materials,2001(1/2):118-126. |
| [8] | Matsumine A;Takegami K;Asanuma K;Matsubara T;Nakamura T;Uchida A;Sudo A .A novel hyperthermia treatment for bone metastases using magnetic materials.[J].International journal of clinical oncology,2011(2):101-108. |
| [9] | Ruiz-Hernandez E;Serrano MC;Arcos D;Vallet-Regi M .Glass-glass ceramic thermoseeds for hyperthermic treatment of bone tumors.[J].Journal of biomedical materials research, Part A,2006(3):533-543. |
| [10] | Horsman MR;Overgaard J .Hyperthermia: a potent enhancer of radiotherapy.[J].Clinical oncology,2007(6):418-426. |
| [11] | Issels RD .Hyperthermia adds to chemotherapy.[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR),2008(17):2546-2554. |
| [12] | Hildebrandt B;Wust P.The biologic rationale of hyperthermia[A].Boston,MA:Kluwer Academic Publishers,2007:171. |
| [13] | Ikenaga M;Ohura K;Yamamuro T et al.Localized hyperthermic treatment of experimental bone tumors with ferromagnetic ceramics[J].Journal of Orthopaedic Research,1993,11(06):849. |
| [14] | Takegami K;Sano T;Wakabayashi H;Sonoda J;Yamazaki T;Morita S;Shibuya T;Uchida A .New ferromagnetic bone cement for local hyperthermia.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(2):210-214. |
| [15] | Kusaka M;Takegami K;Sudo A;Yamazaki T;Kawamura J;Uchida A .Effect of hyperthermia by magnetite cement on tumor-induced bone destruction.[J].Journal of orthopaedic science: official journal of the Japanese Orthopaedic Association,2002(3):354-357. |
| [16] | Matsumine A;Kusuzaki K;Matsubara T et al.Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field[J].Clinical and Experimental Metastasis,2007,24(03):191. |
| [17] | Fernández E;Vlad M D;Hamcerencu M et al.Effect of iron on the setting properties of α-TCP bone cements[J].Journal of Materials Science,2005,40(14):3677. |
| [18] | M. D. Vlad;D;Vlad;L. J. del Valle;J;del Valle;I. Poeata;Poeata;M. Barracó;Barraco;J. López;Lopez;R. Torres;Torres;E. Fernández;Fernandez .Injectable Iron-modified Apatitic Bone Cement Intended For Kyphoplasty: Cytocompatibility Study[J].Journal of Materials Science. Materials in Medicine,2008(12):3575-3583. |
| [19] | Vlad MD;Sindilar EV;Marinoso M .Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications: in vivo study.[J].Acta biomaterialia,2010(2):607-616. |
| [20] | Kawashita M;Kawamura K;Li Z .PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer.[J].Acta biomaterialia,2010(8):3187-3192. |
| [21] | Li Z;Kawamura K;Kawashita M;Kudo T;Kanetaka H;Hiraoka M. .In vitro assessment of poly(methylmethacrylate)-based bone cement containing magnetite nanoparticles for hyperthermia treatment of bone tumor[J].Journal of biomedical materials research, Part A,2012(10):2537-2545. |
| [22] | 李光大;赵三团;胡志刚 等.一种温控磁性骨水泥及制备方法[P].中国,201210000742,2012-07-11. |
| [23] | Jhamak Nourmohammadi;S.K. Sadmezhaad;A. Behnamghader .In vitro bioactivity of novel cured ionomer cement based on iron oxide[J].CERAMICS INTERNATIONAL,2010(5):1645-1651. |
| [24] | Ana Portela;Mario Vasconcelos;Rogerio Branco;Fatima Gartner;Miguel Faria;Jose Cavalheiro .An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy[J].Journal of Materials Science. Materials in Medicine,2010(8):2413-2423. |
| [25] | 李茂红,屈树新,姚宁,郭悦华,王岳峰,翁杰.药物对磷酸钙骨水泥性能的影响综述[J].材料导报,2009(21):55-58. |
| [26] | Maccauro G;Cittadini A;Casarci M et al.Methotrexateadded acrylic cement:Biological and physical properties[J].Journal of Materials Science:Materials in Medicine,2007,18(05):839. |
| [27] | Lebugle A;Rodrigues A;Bonnevialle P;Voigt JJ;Canal P;Rodriguez F .Study of implantable calcium phosphate systems for the slow release of methotrexate.[J].Biomaterials,2002(16):3517-3522. |
| [28] | 杨志平,韩键,李昕,李建民.含甲氨喋呤的磷酸钙骨水泥药物释放体系的制备及体外药物释放[J].中国医学科学院学报,2007(06):765-768. |
| [29] | Dong Li;Zhiping Yang;Xin Li;Zhenfeng Li;Jianmin Li;Jingyan Yang .A histological evaluation on osteogenesis and resorption of methotrexate-loaded calcium phosphate cement in vivo[J].Biomedical materials,2010(2):025007:1-025007:7. |
| [30] | Tanzawa Y;Tsuchiya H;Shirai T et al.Potentiation of the antitumor effect of calcium phosphate cement containing anticancer drug and caffeine on rat osteosarcoma[J].Journal of Orthopaedic Science,2011,16(01):77. |
| [31] | 刘彦宁,刘淼,任鹏宇.磷酸钙骨水泥/氨磷汀/顺铂复合体体外药物缓释及体内修复骨缺损和抑瘤实验[J].四川大学学报（医学版）,2010(03):471-475. |
| [32] | Tani T;Okada K;Takahashi S;Suzuki N;Shimada Y;Itoi E .Doxorubicin-loaded calcium phosphate cement in the management of bone and soft tissue tumors.[J].In Vivo: International Journal of In Vivo Research,2006(1):55-60. |
| [33] | 敦先礼,李有方,王光勇,周廷玉,李锋.阿霉素骨水泥在椎体肿瘤重建中的应用[J].中国医师杂志,2008(03):397-399. |
| [34] | 孙强,郑加法,刘德南.聚甲基丙烯酸甲酯骨水泥作为抗肿瘤药物缓释载体的实验研究[J].中华肿瘤防治杂志,2010(11):823-826. |
| [35] | 孙诚,徐晓明,齐朝月.骨水泥中抗癌药的释放、活性及抗肿瘤效应的实验研究[J].中国医学影像学杂志,2007(04):273-275. |
| [36] | Lopez Heredia MA;Kamphuis GJ;Thune PC;Oner FC;Jansen JA;Walboomers XF .An injectable calcium phosphate cement for the local delivery of paclitaxel to bone.[J].Biomaterials,2011(23):5411-5416. |
| [37] | Konishi H;Honda M;Aizawa M et al.Biochemical studies of the potential anti-tumor activity of novel chelate-setting apatite cements[J].Key Engineering Materials,2012,493-494:315. |
| [38] | 刘珂,金毅,王小刚.抗肿瘤骨水泥研究现状与进展[J].中华实用诊断与治疗杂志,2011(03):211-213. |
| [39] | 薛忠林 .包裹多柔比星PLGA微球骨水泥的研制及其成骨和抗肿瘤[D].广州:南方医科大学,2009. |
| [40] | Anselmetti,G.C.;Manca,A.;Hirsch,J.;Montemurro,F.;Isaia,G.;Osella,G.;Chiara,G.;Iussich,G.;Debernardi,F.;Regge,D. .Percutaneous vertebroplasty in osteoporotic patients: An institutional experience of 1,634 patients with long-term follow-up[J].Journal of vascular and interventional radiology: JVIR,2011(12):1714-1720. |
| [41] | Kaneko TS;Sehgal V;Skinner HB;Al Ghazi MS;Ramisinghani NS;Keyak JH .Evaluation of a radiation transport modeling method for radioactive bone cement.[J].Physics in medicine and biology,2010(9):2451-2463. |
| [42] | Kaneko,T.S.;Sehgal,V.;Skinner,H.B.;Al-Ghazi,M.S.A.L.;Ramsinghani,N.S.;MarquezMiranda,M.;Keyak,J.H. .Radioactive bone cement for the treatment of spinal metastases: A dosimetric analysis of simulated clinical scenarios[J].Physics in medicine and biology,2012(13):4387-4401. |
| [43] | Lu J;Deng J;Zhao H;Shi M;Wang J;Zhao L .Safety and feasibility of percutaneous vertebroplasty with radioactive (153)Sm PMMA in an animal model.[J].European Journal of Radiology,2011(2):296-301. |
| [44] | Ashamalla H;Cardoso E;Macedon M .Phase I trial of vertebral intracavitary cement and samarium (VICS): novel technique for treatment of painful vertebral metastasis.[J].International Journal of Radiation Oncology, Biology, Physics,2009(3):836-842. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%