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  4. PLGA微球包埋药物的稳定性及释放研究的新进展

功能材料, 2011, 42(z4): 591-595.

PLGA微球包埋药物的稳定性及释放研究的新进展

王明波 1, , 冯庆玲 2, , 佘振定 3, , 谭荣伟 4,

1.清华大学材料科学与工程系,先进材料教育部重点实验室,北京100084;清华深圳大学研究院,深圳市生物医用材料及植入器械重点实验室,广东深圳518057

2.清华大学材料科学与工程系,先进材料教育部重点实验室,北京100084

3.清华大学材料科学与工程系,先进材料教育部重点实验室,北京100084;清华深圳大学研究院,深圳市生物医用材料及植入器械重点实验室,广东深圳518057

4.清华大学材料科学与工程系,先进材料教育部重点实验室,北京100084

基金项目:   国家自然科学基金资助项目(51072090;51061130554)  

关键词： PLGA微球 , 药物稳定性 , 释放曲线 , 降解 , 酸性问题

Latest research progress of drug stability and release of PLGA microspheres

乳酸-乙醇酸共聚物[ poly( lactide-co-glycolide),PLGA]是一种前景良好的可降解合成高分子材料,作为缓释给药系统的基体材料被广泛研究.这主要基于其优异的生物相容性、可调控的生物降解性,以及已被欧美药监局批准等优点.微球缓释给药可延长药物的半衰期,增加临床治疗效果,在医药行业和生物材料领域备受推崇.药物的稳定性和释放动力学特征是微球研究中的两个关键问题,也主导着临床治疗的效果.围绕最近两年关于PLGA微球所载药物的稳定性及释放动力学的研究报道,结合本课题组在PLGA微球加载骨生长因子(人重组骨形态发生蛋白rhBMP-2及其相关多肽)方面的工作作一个综述.同时,总结了现有国内外主要的PLGA微球产品,展望了微球载药体系的前景.

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