医用钛表面生物活性化研究

功能材料, 2005, 2(z1): 23-27.

医用钛表面生物活性化研究

冯波 ^1, , 翁杰 ^2, , 屈树新 ^3, , 陈继镛 ^4, , 张兴栋 ^5,

1.西南交通大学,材料先进技术教育部重点实验室,材料科学与工程学院,四川,成都,610031

2.西南交通大学,材料先进技术教育部重点实验室,材料科学与工程学院,四川,成都,610031

3.西南交通大学,材料先进技术教育部重点实验室,材料科学与工程学院,四川,成都,610031

4.四川大学,生物材料工程研究中心,四川,成都,610064

5.四川大学,生物材料工程研究中心,四川,成都,610064

基金项目: 中国科学院资助项目(30370408)

关键词：钛 , 生物活性 , 表面改性 , 羟基磷灰石 , 蛋白质 , 细胞

Progress in the surface bioactivation for titanium in medicine

钛及钛合金具有优良的生物相容性和机械性能,已应用于临床,尤其是用作骨替换与修复材料.但是,钛属于生物惰性材料,不能与骨组织形成化学键合或称骨键合.通过表面改性可使其在生理环境具有诱导羟基磷灰石在表面自发生长的能力,即生物活性化.这是当今生物医用材料研究的热点领域之一.本文评述了钛表面生物活化的研究现状,简要总结了本课题组在这方面的研究工作.

参考文献

[1]	Van Noort R .[J].Journal of Materials Science,1987,22:3801-3811.
[2]	Ducheyne P;Bianco P;Radin S.Bone-bonding biomaterials[A].Leiderdorp.the Netherlands,1992:1-12.
[3]	Hench L L;Wilson J .[J].Science,1984,226:630-636.
[4]	Hulbert S F;T Yamamuro;L L Hench;J Wilson.CRC Handbook of bioactive ceramics[M].CRC Press.Boston,1990:3-6.
[5]	Li P;Ohtsuki C;Kokubo T et al.[J].Journal of Biomedical Materials Research,1994,28:7-15.
[6]	Lee J;Aoki H .[J].Biomedical Materials & Engineering,1995,5:49-58.
[7]	Weng J.;Li XD.;Zhang XD.;Liu XG. .INTRINSIC FACTORS OF APATITE INFLUENCING ITS AMORPHIZATION DURING PLASMA-SPRAY COATING[J].Biomaterials,1995(1):39-44.
[8]	Chen J;Wolke J G C;De Groot K .s[J].Biomaterials,1994,15:396-399.
[9]	Ong J L;Lucas L C;Lacefield W R et al.[J].Biomaterials,1992,13:249-254.
[10]	Hanawa T;Ukai H;Murakami K et al.[J].Materials Transactions,1995,36:438-444.
[11]	Ding SJ;Ju CP;Lin JH .Characterization of hydroxyapatite and titanium coatings sputtered on Ti-6Al-4V substrate.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1999(3):266-279.
[12]	Shirkhanzadeh M .[J].Journal of Materials Science:Materials in Medicine,1995,6:90-93.
[13]	Chen JS.;Hon MH.;Juang HY. .Calcium phosphate coating on titanium substrate by a modified electrocrystallization process[J].Journal of Materials Science. Materials in Medicine,1998(5):297-300.
[14]	Ban S;Maruno S;Airmoto A et al.[J].Journal of Biomedical Materials Research,1997,36:9-15.
[15]	Ishizawa H;Ogino M .P[J].Journal of Biomedical Materials Research,1997,34:15-20.
[16]	Tengvall P;Elwing H;Lundstrom I .[J].Journal of Colloid and Interface Science,1989,130:405-413.
[17]	Ohtsuki C;Iida H;Hayakawa S et al.[J].Journal of Biomedical Materials Research,1997,35:39-47.
[18]	Li P;Ohtsuki C;Kokubo T.[J].Journal of the American Ceramic Society,1992:752094-2097.
[19]	Peltola T;Patsi M;Rahiala H;Kangasniemi I;Yli-Urpo A .Calcium phosphate induction by sol-gel-derived titania coatings on titanium substrates in vitro.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(3):504-510.
[20]	Kim H M;Miyaji F;Kokubo T et al.[J].Journal of Biomedical Materials Research,1997,38:121-127.
[21]	Wen HB.;De Wijn JR.;De Groot K.;Cui FZ.;Liu Q. .Preparation of bioactive microporous titanium surface by a new two-step chemical treatment[J].Journal of Materials Science. Materials in Medicine,1998(3):121-128.
[22]	Bunker B C;Rieke P C;Tarasevieh B J et al.[J].Science,1994,264:48-55.
[23]	Healy K;Ducheyne P .[J].Biomaterials,1992,13:553-561.
[24]	Sautier J M;Nefussi J R;Forest N .[J].Biomaterials,1992,13:400-402.
[25]	Sinha R K;Morris F;Shah S A et al.[J].Clinical Orthopaedics & Related Research,1994,305:258-272.
[26]	Puleo D A;Bizios R .[J].Journal of Biomedical Materials Research,1992,26:291-301.
[27]	Lampin M;Warocquier-Clerout R;Legris C et al.[J].Journal of Biomedical Materials Research,1997,86:99-108.

上一张下一张

计量

下载量()
访问量()

作者相关

文章评分

您的评分：
1

0%
2

0%
3

0%
4

0%
5

0%

材料期刊网

医用钛表面生物活性化研究

Progress in the surface bioactivation for titanium in medicine

参考文献