采用无皂乳液聚合法制备了Fe3O4/(PNIPAAm-co Am)复合微球,采用DLS测试手段对复合微球的温敏性进行了表征,采用维生素B12为药物模型,研究了复合微球在不同温度及交变磁场作用下的药物缓释行为,并对其药物缓释机理进行了探讨.结果表明,所制备的复合微球LCST约为40℃,具有良好的药物缓释效果,采用间歇式交变磁场作用复合微球,可显著提高药物的累积释放率,在肿瘤热疗与化疗联合治疗方面具有良好的应用前景.
参考文献
| [1] | Soyeon Kim;Kevin E.Healy .Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links[J].Biomacromolecules,2003(5):1214-1223. |
| [2] | Klouda L;Mikos AG .Thermoresponsive hydrogels in biomedical applications.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2008(1):34-45. |
| [3] | 隋静,胡娜,施冬健,尚跃再,陈明清.PDEAm接枝PAN/PSt温敏性聚合物微球的制备及表征[J].功能材料,2012(01):133-136. |
| [4] | 高正国,崔媛,陶祥东,韩双丽,段潜.端糖基化聚（N-异丙基丙烯酰胺）的合成及其温敏性表征[J].功能材料,2012(02):190-195. |
| [5] | Ankareddi I;Brazel CS .Synthesis and characterization of grafted thermosensitive hydrogels for heating activated controlled release.[J].International Journal of Pharmaceutics,2007(2):241-247. |
| [6] | Purushotham S;Ramanujan RV .Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy.[J].Acta biomaterialia,2010(2):502-510. |
| [7] | Zhang J;Misra RD .Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response.[J].Acta biomaterialia,2007(6):838-850. |
| [8] | Miller S .Magnetic fluid hyperthermia therapy for malignant brain tumors-an ethical discussion[J].Nano-medicine:NBM,2009,5:387-393. |
| [9] | Issels RD .Hyperthermia adds to chemotherapy.[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR),2008(17):2546-2554. |
| [10] | Zhang JL;Srivastava RS;Misra RDK .Core-shell magnetite nanoparticles surface encapsulated with smart stimuli-responsive polymer: Synthesis, characterization, and LCST of viable drug-targeting delivery system[J].Langmuir: The ACS Journal of Surfaces and Colloids,2007(11):6342-6351. |
| [11] | Hirotake Wakamatsu;Kazuya Yamamoto;Aiko Nakao .Preparation and characterization of temperature-responsive magnetite nanoparticles conjugated with N-isopropylacrylamide-based functional copolymer[J].Journal of Magnetism and Magnetic Materials,2006(2):327-333. |
| [12] | 艾凡荣,姚爱华,黄文旵,王德平.磁场-温度双重响应性复合微球的制备与表征[J].高等学校化学学报,2010(09):1701-1705. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%