自然骨的组成和结晶度均不同于人工合成的羟基磷灰石[Ca10(PO4)6(OH)2,hydroxyapatite,HA],是一种典型的缺钙羟基磷灰石,还含有镁(Mg)、锶(Sr)、钠(Na)、钾(K)、氟(F)等离子.为满足临床要求,常常需要在HA中添加一些元素来改善其性能.含镁羟基磷灰石(Mg-HA)就是其中的一类改性材料.以四水硝酸钙[Ca(NO3)2·4H2O]、磷酸氢二铵[(NH4)2HPO4]、六水硝酸镁[Mg(NO3)2·6H2O]为原料,在180℃下水热处理8h制得Mg-HA.通过XRD、IR、TEM 、EDX和TG/DTA对Mg-HA的晶相、化学组成、形貌和热稳定性进行分析,并通过细胞培养,MTT比色法对材料的细胞毒性进行评价.结果表明,Mg取代部分钙(Ca)进入HA的晶格中.随着Mg含量的提高,Mg-HA晶粒尺寸呈减小趋势,热稳定性降低,掺镁对羟基磷灰石细胞毒性影响较小,Mg-HA具有较好的生物相容性.
参考文献
| [1] | Shi Donglu.Nanoscience in Biomedicine[M].北京:清华大学出版社,2006 |
| [2] | Ilich JZ;Kerstetter JE .Nutrition in bone health revisited: a story beyond calcium.[J].Journal of the American College of Nutrition,2000(6):715-737. |
| [3] | Kakei M;Nakahara H;Tamura N et al.[J].Annals of Anatomy Anatomischer Anzeiger,1997,179(04):311-316. |
| [4] | Akemi Y;Takashi Y;Kazuhiko K et al.[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2004,238(1-3):133-139. |
| [5] | Elena Landi;Anna Tampieri;Monica Mattioli-Belmonte .Biomimetic Mg- and Mg,CO_3-substituted hydroxyapatites: synthesis characterization and in vitro behaviour[J].Journal of the European Ceramic Society,2006(13):2593-2601. |
| [6] | Landi, E;Logroscino, G;Proietti, L;Tampieri, A;Sandri, M;Sprio, S .Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour[J].Journal of Materials Science. Materials in Medicine,2008(1):239-247. |
| [7] | Serre CM;Papillard M;Chavassieux P;Voegel JC;Boivin G .Influence of magnesium substitution on a collagen-apatite biomaterial on the production of a calcifying matrix by human osteoblasts.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(4):626-633. |
| [8] | Tampieri A;Celotti G;Landi E.[J].Key Engineering Materials,2004(264-268):2051-2054. |
| [9] | Guochao;Sam Zhang;Khiam Aik Khor;Sun Woh Lye;Xianting Zeng;Wenjian Weng;Chunming Liu;Subbu S. Venkatraman;Lwin Lwin Ma .Osteoblastic Cell Response On Magnesium-incorporated Apatite Coatings[J].Applied Surface Science: A Journal Devoted to the Properties of Interfaces in Relation to the Synthesis and Behaviour of Materials,2008(2):304-307. |
| [10] | Bouyer E;Gitzhofer F;Boulos M I .[J].Journal of Materials Science:Materials in Medicine,2000,11:523-531. |
| [11] | Guerra-López J;Pomés R;Della Védova C O et al.[J].Journal of Raman Spectroscopy,2001,32(04):255-261. |
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