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The electromagnetic features of biomacromolecules are foundation of interaction between the millimeter waves and living systems. Therefore we first reveal the electromagnetic features of biomacromolecules, for example, protein, DNA and lipid. Next we calculate the rotational energy-spectra of these biomacromolecules by quantum mechanical theory. The transitions of electrons between the rotational energy-levels can result in radiations or absorptions of millimeter waves. Thus we propose the mechanism and properties of non-thermally biological effect of the millimeter waves, i.e., the millimeter waves are absorbed by these biomacromolecules which can result in rotation and changes of conformations of these molecules, thus the energy of the millimeter waves are to be transformed as the mechanical energy of the conformation changes of the biomacromolecules, but not as thermal energy of motions of these biomacromolecules to increase their temperature. This mechanism is verified by experiments of conformation changes of the protein and amino acid molecules exposed under the millimeter waves. These rotations of conformations of these molecules can results in obvious biological effects. We study the features of the biological effects.

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