采用季铵化魔芋葡甘聚糖(CMKGM)对钠基蒙脱石(MMT)进行改性制备有机蒙脱石(CMKGM-MMT),并对改性后的蒙脱石进行红外光谱(FT-IR)和X射线衍射(XRD)等分析表征.结果表明,当制备季铵化魔芋葡甘聚糖改性蒙脱石时,反应条件pH值为4.6、反应温度为60 ℃,且CMKGM的用量是MMT的1.0倍阳离子交换容量时(CMKGM和MMT的质量比为0.9),形成的插层型有机蒙脱石的有机化程度最高,并考察了改性蒙脱石的体外细胞毒性及其对牛血清白蛋白(BSA)的载药性能.
Quaternized KGM (CMKGM) was used to modify montmorillonite (MMT) to prepare organic montmorillonite (CMKGM-MMT).The structure of modified montmorillonite was characterized by infrared spectroscopy (FT-IR) and X-ray diffraction (XRD).The results show that quaternized KGM indeed intercalate into the layers of montmorillonite and form intercalated organic montmorillonite with the highest organic modification when the amount of CMKGM is equivalent to 1.0 CEC of MMT(the mass ratio between CMKGM and MMT is 0.9) under the condition of 60 ℃ at pH=4.6.Then the in vitro cytotoxicity and the drug loading property of the complexes were investigated.
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