以羧甲基纤维素增强半水硫酸钙，使其更适合应用于骨修复。通过抗压性能测试确定了优化的纤维用量，纤维比例为3%时抗压能力约为42 MPa。借助X射线衍射和电镜扫描分析手段，探索了纤维用量对基质结晶种类和纤维分布的影响，结果表明纤维用量过多将导致分散不均、易产生二水硫酸钙而影响强度。通过磷酸缓冲盐溶液培养测试证明，加入羧甲基纤维素后半水硫酸钙的耐溃散性能得到显著提高。
The carboxymethyl cellulose were used to reinforce calcium sulfate hemihydrates ( CSH ) to make it more suitable for bone repair. The compressive strength of the composites was evaluated and an optimistic fiber level was concluded. When 3% cellulosic fiber was added to CSH the resulted composite could stand 42 MPa compressive force. By using X-ray diffraction scans and electric scan microscope, the crystal of CSH and distribution of fibers were analyzed. Excessive fibers resulted in the uneven distribution in CSH matrix and creation of calcium sulfate dihydrate, which would decrease the compressive strength of the composites. The result of soaking samples in phosphate buffer solution proved that the anti-washout of CSH obviously improved when carboxymethyl cellulose were introduced.
参考文献
| [1] | Chapman MW;Bucholz R;Cornell C.Treatment of acute fractures with a collagen-calcium phosphate graft material. A randomized clinical trial.[J].The Journal of Bone and Joint Surgery. American Volume,19974(4):495-502. |
| [2] | Brandoff JF;Silber JS;Vaccaro AR.Contemporary alternatives to synthetic bone grafts for spine surgery.[J].The American journal of orthopedics,20088(8):410-414. |
| [3] | 张闻力;刘浩;李坛珠;宋跃明;龚全;李涛;刘立岷.医用硫酸钙人工骨在脊柱结核手术中的应用[J].中国矫形外科杂志,2007(9):652-655. |
| [4] | 衷鸿宾;侯树勋;姚长海;吴闻文;张伟佳;史亚明;解英俊.冷冻干燥同种骨临床应用的初步报告[J].中国矫形外科杂志,2003(16):1093-1095. |
| [5] | 陈龙成;郝建东.胫骨平台骨折的研究进展[J].河北医药,2014(8):1222-1225. |
| [6] | 刘爱红;孙康宁;赵萍.磷酸钙骨水泥的研究进展[J].材料导报,2005(2):17-19,30. |
| [7] | 王小红;马建标;王亦农;何炳林.骨修复材料的研究进展[J].生物医学工程学杂志,2001(4):647-652. |
| [8] | 曹德勇;宋雪峰;陈亦平;卢绍杰;姚康德.骨水泥生物材料研究与开发进展[J].化学工业与工程,2003(5):303-309. |
| [9] | Hata K.;Nakamura T.;Yamamuro T.;Kokubo T..GROWTH OF A BONELIKE APATITE LAYER ON A SUBSTRATE BY A BIOMIMETIC PROCESS[J].Journal of the American Ceramic Society,19954(4):1049-1053. |
| [10] | 王丹.可降解多孔β-TCP/rhBMP-2人工骨的骨诱导活性研究[J].中华骨科杂志,1998(11):689. |
| [11] | 朱海 .丝素蛋白/硫酸钙骨水泥的制备及其理化性能测试[D].苏州大学,2014. |
| [12] | 陈华 .医用外科级α-半水硫酸钙的研制及其相关研究[D].中国人民解放军军医进修学院,2006. |
| [13] | 郭明刚.硫酸钙在骨损伤修复中的研究进展[J].西部医学,2015(07):1119-1120,封3. |
| [14] | 胡堃;刘斌.骨移植材料发展趋势[J].生物骨科材料与临床研究,2010(3):32-38. |
| [15] | 许晨辉;何阿祥;谢栋;陈洁;魏杰;杨立利.介孔钙硅酸盐改性硫酸钙骨水泥的体内降解及成骨性能[J].中国矫形外科杂志,2016(6):544-551. |
| [16] | 陈晨 .短期可吸收骨创面止血纳米生物玻璃/壳聚糖/羧甲基纤维素复合材料的研制[D].复旦大学,2013. |
| [17] | 肖海军 .预防粘连羧甲基壳聚糖复合膜的制备工艺及医学应用实验研究[D].第二军医大学,2006. |
| [18] | 蒋柳云;李玉宝;张利;廖建国;杨维虎.纳米羟基磷灰石/壳聚糖/羧甲基纤维素三元复合骨修复材料的制备和性能研究[J].功能材料,2007(5):798-801. |
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