在反相乳液体系中合成β—CD微球载体，使其对甲芬那酸进行包合；通过L9（3^4）正交实验对包合条件进行优化，并采用电镜扫描、红外、X射线衍射和热重对微球及包合物进行了表征，结果表明最佳包合条件为β—CD微球1g，甲芬那酸的浓度0．003g／mL，反应时间3h，反应温度70℃。通过紫外分光光度法测定最佳包合条件下的载药量为1．90％，包封率为79．2％，影响因素的主次顺序为载药温度〉β-CD微球的量〉甲芬那酸的浓度〉载药时间。
The β-cyclodextrin microspheres were synthesized in inverse emulsion , then its adsorption to mefenamic acid were studied . The preparation process was optimized through the L^9 (3^4) orthogonal experimental design and the structure and performance were characterized by scanning electron microscope, FT-IR spectroscopy, X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The results showed that the most optimized conditions were as following, m (β-CD microsphere/g) lg, mefenamic acid concentration 0. 003g/mL, time 3h, temperature 70℃ Drug loadings and sealed rate were 1.90% and 79.2% ,respectively at the most optimized conditions by means of ultraviolet spectrophotometry. The sequence of influence factors was the reaction temperature 〉 the quantity of β-cyelodextrin microsphere 〉 the concentration of mefenamic acid 〉 the reac tion time.
参考文献
| [1] | 吴寅,文爱东,罗晓星,谢黎,杨志福,陈平君,李薇,赵磊.甲芬那酸分散片在健康人体的生物等效性评价[J].中国医院药学杂志,2005(11):1013-1016. |
| [2] | Lethaby A;Augood C;Duckitt K.Nonsteroidal anti-in- flammatory drugs for heavy menstrual bleeding[J].Co- chrane Database Syst Rev,2002(01):CD000400. |
| [3] | Al Waili-NS .Treatment of menstrual migraine with prostaglandin synthesis inhibitor mefenamic acid: double-blind study with placebo.[J].European journal of medical research,2000(4):176-182. |
| [4] | 林伟丰,杨琳,陈缵光,李全文,蔡沛祥,莫金垣.毛细管电泳测定甲芬那酸制剂及体液中的甲芬那酸[J].分析科学学报,2006(04):381-384. |
| [5] | 刘雁,李志军.非甾体抗炎药物的药理及临床应用进展[J].中国医院药学杂志,2000(12):748-750. |
| [6] | 钱春梅,陶小军,曾爱国.甲芬那酸包合物和固体分散体的研究[J].西安交通大学学报(医学版),2003(06):581-583,591. |
| [7] | 陈树薇,施文健,宋伟,秦琴,张元璋,高隽臣.壳聚糖交联β-环糊精对酸性染料吸附动力学和热力学研究[J].功能材料,2009(04):656-659. |
| [8] | Jia Yunling;Shang Yanli;Ma Jun et al.Preparation and electrorheologieal performance of 3-eyclodextrin inclusion compound doped with carbon fibre[J].Journal of Func- tional Materials,2006,37(05):696-699. |
| [9] | Yang Qin;Yang Yongli;Wang Wendong et al.Study on 13-cyclodextrin and metal phthaloeyanine effects of func- tional assembly[J].Journal of Functional Materials,2011,42(07):1293-1296. |
| [10] | Romo A;Peas F J;Isasi J R et al.Extraction of phenols from aqueous solutions by 13-cyelodextrin polymers com- parison of sorptive capacities with other sorbents[J].Re- active Functional Polymers,2008,68:406-413. |
| [11] | Zhang Weifen;Chen Xiguang;Li Piwu et al.Preparation and characterization of the ophylline loaded chitosan/l]- cyclodextrin microspheres[J].Journal of Materials Science:Materials in Medicine,2008,19:305-310. |
| [12] | Gao ZW.;Zhao XP. .Enhancing electrorheological behaviors with formation of beta-cyclodextrin supramolecular complex[J].Polymer: The International Journal for the Science and Technology of Polymers,2003(16):4519-4526. |
| [13] | Arakawa Y;Kawakami S;Yamashita F;Hashida M .Effect of low-molecular-weight beta-cyclodextrin polymer on release of drugs from mucoadhesive buccal film dosage forms.[J].Biological & pharmaceutical bulletin,2005(9):1679-1683. |
| [14] | GAO Ziwei,ZHAO Xiaopeng,SUN Ping,SI Gang.Supramolecular complex formation of β-cyclodextrin polymer with substituted salicylic acid or 3-hydroxy-2-naphthoic acid and their electrorheological behaviors[J].中国科学B辑(英文版),2004(04):340-348. |
| [15] | 中国药典(2000版二部)[S].北京:人民卫生出版社,2000. |
| [16] | 李仲谨,杨威,刘艳,赵燕,李健基.β-环糊精聚合物微球对Zn2+的吸附行为及机理[J].食品科学,2011(01):35-38. |
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