以1-乙基-3-(3-二甲基氨丙基)碳二亚胺(EDC)为偶联剂,将由N'N-二甲基甲酰胺(DMF)活化的脱氧胆酸接枝到海藻酸钠主链的羧基上,得到疏水改性的双亲性海藻酸钠(DSA),DSA在水相自组装形成纳米颗粒,利用紫外荧光分光光度计、动态激光光散射仪和原子力显微镜对其结构性质进行表征,平均粒径为208.7nm,粒径尺寸比较均一且分布较窄,具有较低的临界聚集浓度(critical aggregation concentration,CAC),而且随着取代度的不断提高,临界聚集浓度不断降低,并将其作为鱼藤酮载体实验发现载药效果良好.
参考文献
[1] | Tobio M;Gref R;Sanchez A;Langer R;Alonso MJ .Stealth PLA-PEG nanoparticles as protein carriers for nasal administration.[J].Pharmaceutical research,1998(2):270-275. |
[2] | Kwon G S;Okano T .[J].Advanced Drug Delivery Reviews,1996,21(02):107-116. |
[3] | Kataoka K;Harada A;Nagasaki Y et al.[J].Advanced Drug Delivery Reviews,2001,47:113-131. |
[4] | 徐汉虹,黄继光.鱼藤酮的研究进展[J].西南农业大学学报,2001(02):140-143. |
[5] | Zhao Shanhuan;Huang Zhangxin .[J].Plant Protection,1988,14(01):44-45. |
[6] | 莫美华,黄彰欣,董群娟.鱼藤酮及其混剂对蔬菜害虫的毒效研究[J].华南农业大学学报,1994(04):58-62. |
[7] | Park K;Kim K;Kwon I C et al.[J].Langmuir,2004,20:11726-11731. |
[8] | Srokova I;Tomanova V;Ebringerova A et al.[J].Macromolecular Materials and Engineering,2004,289:63-69. |
[9] | Liu C G;Chen X G;Park H J .[J].Carbohydrate Polymers,2005,62:293-298. |
[10] | Liu CG;Desai KG;Chen XG;Park HJ .Linolenic acid-modified chitosan for formation of self-assembled nanoparticles[J].Journal of Agricultural and Food Chemistry,2005(2):437-441. |
[11] | Nouvel C;Frochot C;Sadtler V et al.[J].Macromolecules,2004,37:4981-4988. |
[12] | Kalyanasundaram K;Thomas J K .[J].Journal of the American Chemical Society,1977,99:2039-2044. |
[13] | Hu Y;Jiang X;Ding Y;Zhang L;Yang C;Zhang J;Chen J;Yang Y .Preparation and drug release behaviors of nimodipine-loaded poly(caprolactone)-poly(ethylene oxide)-polylactide amphiphilic copolymer nanoparticles.[J].Biomaterials,2003(13):2395-2404. |
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