利用静电纺丝法和溶液法分别制备了具有微纳米纤维结构、串珠结构和较密实结构的聚乳酸/辣椒素复合载药薄膜(分别称为薄膜Ⅰ、薄膜Ⅱ和薄膜Ⅲ).研究了不同载药量(5％、1o％和15％,质量分数)和不同微结构对药物释放行为的影响.药物释放研究表明:PLA/Cap复合载药薄膜的微结构和载药量都对药物释放行为有重要的影响.当载药量为5％和10％(质量分数)时,药物释放行为主要受载药薄膜的微结构影响,释放速度由快到慢为:薄膜Ⅰ、薄膜Ⅱ、薄膜Ⅲ;随着载药量的增加药物释放速度加快,且3种载药薄膜的辣椒素释放速度之间的差别减小.当载药量达15％(质量分数)时,载药量对药物释放行为的影响较微结构的影响更加显著,3种载药薄膜的药物释放行为接近.
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