用1,1,1-三羟甲基乙烷及2,2-二羟甲基丙酸为原料合成了树型分子R(CH_2OH)_6;然后以此树形分子引发ε-己内酯开环聚合,得到了六臂星形聚己内酯(Star PCL);再通过DCC使叶酸与星形聚己内酯各臂链端的羟基官反应,得到了链端接枝叶酸的星形聚己内酯(StarPCL-FA).~1H-NMR和FT-IR确证了产物的结构.结果表明,成功地制备了六臂星形聚己内酯-叶酸材料,它们有望成为一类新型的肿瘤靶向药物载体材料.
Star-shaped poly(ε-caprolactone)s (Star PCLs) with six arms were successfully synthesized via ring-opening polymerization of ε-caprolactone initiated by a dendrimer which was synthesized by TME and 2,2-bishydroxymethylepropanoic acid.Then by conjugating the end hydroxyl groups of Star PCLs with the carboxyl groups of folic acid,star-shaped poly(ε-caprolactone)s with folates (Star PCL-FAs) were obtained.Characterizations of these materials by ~1H-NMR,FT-IR were carried out.The results showed that the arm number of the Star PCLs was in accordance with the hydroxyl group number of the initiator and the conjugation of folic acid was successful.These polymers are expected to be used as drug carriers for targeted drug delivery.
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