由过渡金属Cu(Ⅱ)、苯妥英(Hpht)与苄胺(ba)反应,得到一种新型双核铜配合物[Cu(pht)_2(ba)_2]_2,通过元素分析、摩尔电导、红外光谱、X-射线单晶衍射等对配合物的结构进行了解析和表征.结果表明:该晶体属三斜晶系,空间群为P_1~-,晶胞参数:a=1.0554(15) nm,b=1.201(17) nm,c=1.489(2) nm,α=93.24(2) °,β=102.14(2) °,γ=91.79(2) °,V=1.840(5) nm~3,F(000)=814,Z=1,Dc=1.408 g·cm~(-3),μ=0.648 mm~(-1),R_1=0.0973, wR_2=0.1929.配合物分子中每个Cu(II)离子以N4O1的五配位形式位于变形的三角双锥构型中.利用琼脂扩散法测试了该配合物的抑菌活性,结果表明对4种受试细菌均有一定的活性.
A new dinuclear copper(II) complex [Cu(pht)_2(ba)_2]_2 was synthesized using 5,5-diphenylimidazoline-2,4-dione, benzylamine and copper acetate as raw materials. The complex was characterized by elemental analysis, molar conductance, IR spectrum and single crystal X-ray diffraction. The compound crystallizes in the triclinic system, space group P_1~- with :a=1.0554(15) nm,b=1.2012(17) nm,c=1.4893(2) nm,α=93.24(2) °,β=102.14(2) °,γ=91.79(2) °,V=1.840(5)nm~3,F(000)=814,Z=1,Dc=1.408 g·cm~(-3),μ=0.648 mm~(-1), the final R_1=0.0973 and wR_2=0.1929.Each Cu(II) is a N4O1 coordination environment with the coordination number five and forms a distortional tetragonal pyramid. The complex was valued for its antimicrobial activity against by agar diffusion method in vitro. It was found to be active against the four test bacterial organisms.
参考文献
| [1] | Milne P;H M;Weaver D F .Interaction of Anticonvulsant Drugs with Metals:A Semi-empirical Molecular Orbital Study of Phenytoin-zinc(II) Cpmplexation[J].J Mo Struct,1999,492:19-28. |
| [2] | Nokhodchi A;Bolourtchian N;Dinarvand R .Crystal modification of phenytoin using different solvents and crystallization conditions.[J].International Journal of Pharmaceutics,2003(1):85-97. |
| [3] | Akitsu T;Einaga Y .Tran-bis(5,5-diphenylhydantointo)bis(5,5-diphenylhydantointo) (2-phenylethylamine) Copper(II)[J].Acta Crystallographica,2004,E61:m524-m526. |
| [4] | Akitsu T;Einaga Y .Tran-bis(2,2-diphenylethylamine-κN) bis(5,5-diphenylhydantointo-κN3) Copper(II) and its Chloroform Disolvate[J].Acta Crystallographica,2005,C61:m183-m186. |
| [5] | Akitsu T;Komorita S;Kushi Y .Preparation and Crystal Structures of Trans-bis (imidato) bis (1,2-di phenylethylamine) Copper(II) Complexes (imidato = 5,5-diphenylhydantointo and succinimidato)[J].Inorganica Chimica Acta,2001,315:18-25. |
| [6] | Akitsu T.;Komorita S.;Tamura H. .Diastereomers of copper(II) complexes exhibiting difference in coordination geometry by R- or S-1-phenylethylamine ligands in the solid state and structural conversion of crystals into solutions[J].Inorganica Chimica Acta,2003(0):25-32. |
| [7] | Mau Sinha Ray;Gurucharan Mukhopadhyay;Michael G. B. Drew;Tian-Huey Lu;Siddhartha Chaudhuri;Ashutosh Ghosh .A diphenoxo bridged antiferromagnetically coupled dimer of copper(II) having bridging methanol[J].Inorganic Chemistry Communications,2003(7):961-965. |
| [8] | Hu X L;Xu X Y;Wang D Q et al.Trans-Diaquabis(5,5-diphenylhydantointo-κN3)Copper(II)[J].Acta Crystallographica,2006,E62:m1922-m1923. |
| [9] | Hu X L;Xu X Y;Xu T T et al.Bis (5,5-diphenylhydantointo-N3)Copper(II) (2-methyl-3,4,5,6-tetra Hydropyrimidine Solvate[J].Acta Crystallographica,2006,E62:m2221-m2223. |
| [10] | 沈萍;范秀容;李光武.微生物学实验[M].北京:高等教育出版社,1999 |
| [11] | HU Xi-Lan;XU Xing-You;YIN Fu-Jun .Synthesis,Crystal Structure and Antimicrobial Activity of a Novel Ni(II)Complex[J].Chinese journal of structural chemistry,2008(6):733-737. |
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